Literature DB >> 9853879

Precise measurements of intrauterine vascular structures at hysteroscopy in menorrhagia and during Norplant use.

M Hickey1, D Dwarte, I S Fraser.   

Abstract

Using currently available equipment for panoramic hysteroscopy, the size of images viewed cannot be accurately judged because of the magnifying and distorting effects of the objective lens. This study has demonstrated that magnification by the hysteroscope lens can alter the apparent size of images by up to 27%. An additional effect of lens distortion can alter the apparent size of images viewed by up to 28%, depending on the position of the image in the field of view. These effects are independent and may be additive. Thus, the apparent size of intrauterine structures at hysteroscopy may bear little resemblance to their actual size. Image-correction methods are described which reduce the effects of image magnification on the apparent size of an object viewed through the hysteroscope to 7%, and the effect of distortion to 3 %. This technique can greatly improve the accuracy of measurement at hysteroscopy, and has been utilized in this study for the precise measurement of superficial endometrial vascular diameter (mean+/-SEM) in 34 Norplant users (120+/-11.6 microm) and 20 women with spontaneous menorrhagia (74+/-7.2 microm). It has also confirmed the presence of scattered dilated vessels (up to 777 microm in diameter) on the endometrial surface in some Norplant users.

Entities:  

Keywords:  Clinical Research; Contraception; Contraceptive Agents, Female--pharmacodynamics; Contraceptive Agents, Progestin--pharmacodynamics; Contraceptive Agents--pharmacodynamics; Contraceptive Implants; Contraceptive Methods; Developed Countries; Endoscopy; England; Equipment And Supplies; Europe; Examinations And Diagnoses; Family Planning; Hysteroscopy; Levonorgestrel--pharmacodynamics; Measurement; Northern Europe; Physical Examinations And Diagnoses; Research Methodology; Research Report; United Kingdom

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Year:  1998        PMID: 9853879     DOI: 10.1093/humrep/13.11.3190

Source DB:  PubMed          Journal:  Hum Reprod        ISSN: 0268-1161            Impact factor:   6.918


  2 in total

Review 1.  Decidualized human endometrial stromal cells mediate hemostasis, angiogenesis, and abnormal uterine bleeding.

Authors:  Charles J Lockwood; Graciela Krikun; Martha Hickey; S Joseph Huang; Frederick Schatz
Journal:  Reprod Sci       Date:  2009-02       Impact factor: 3.060

2.  Dilated thin-walled blood and lymphatic vessels in human endometrium: a potential role for VEGF-D in progestin-induced break-through bleeding.

Authors:  Jacqueline F Donoghue; C Jay McGavigan; Fiona L Lederman; Leonie M Cann; Lulu Fu; Eva Dimitriadis; Jane E Girling; Peter A W Rogers
Journal:  PLoS One       Date:  2012-02-17       Impact factor: 3.240

  2 in total

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