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Literature DB >> 9852761

The structural and mechanochemical cycle of kinesin.

Abstract

Kinesin is a microtubule-based motor protein that pulls vesicles or organelles towards the plus end of microtubules. Structural changes in the protein that drive motility are coupled to ATP binding and hydrolysis. Here, we attempt to integrate recent structural and kinetic results into a picture of the mechanochemical cycle of kinesin.

Entities: Chemical

Mesh：

Substances：
Nucleotides
Kinesin

Year: 1998 PMID： 9852761 DOI： 10.1016/s0968-0004(98)01278-x

Source DB: PubMed Journal: Trends Biochem Sci ISSN： 0968-0004 Impact factor: 13.807

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Cited

20 in total

Review 1. A rotary molecular motor that can work at near 100% efficiency.

Authors: K Kinosita; R Yasuda; H Noji; K Adachi
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2000-04-29 Impact factor: 6.237

2. Unusual properties of the fungal conventional kinesin neck domain from Neurospora crassa.

Authors: A Kallipolitou; D Deluca; U Majdic; S Lakämper; R Cross; E Meyhöfer; L Moroder; M Schliwa; G Woehlke
Journal: EMBO J Date: 2001-11-15 Impact factor: 11.598

3. Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd.

Authors: Thomas G Wendt; Niels Volkmann; Georgios Skiniotis; Kenneth N Goldie; Jens Müller; Eckhard Mandelkow; Andreas Hoenger
Journal: EMBO J Date: 2002-11-15 Impact factor: 11.598

4. Mobility of taxol in microtubule bundles.

Authors: Jennifer L Ross; D Kuchnir Fygenson
Journal: Biophys J Date: 2003-06 Impact factor: 4.033

5. Equilibrium and transition between single- and double-headed binding of kinesin as revealed by single-molecule mechanics.

Authors: Kenji Kawaguchi; Sotaro Uemura; Shin'ichi Ishiwata
Journal: Biophys J Date: 2003-02 Impact factor: 4.033

10. Carboxypeptidase E cytoplasmic tail-driven vesicle transport is key for activity-dependent secretion of peptide hormones.

Authors: Joshua J Park; Niamh X Cawley; Y Peng Loh
Journal: Mol Endocrinol Date: 2008-01-17

The structural and mechanochemical cycle of kinesin.

Review 1. A rotary molecular motor that can work at near 100% efficiency.

2. Unusual properties of the fungal conventional kinesin neck domain from Neurospora crassa.

3. Microscopic evidence for a minus-end-directed power stroke in the kinesin motor ncd.

4. Mobility of taxol in microtubule bundles.

5. Equilibrium and transition between single- and double-headed binding of kinesin as revealed by single-molecule mechanics.

6. A kinesin switch I arginine to lysine mutation rescues microtubule function.

7. Kinesin's second step.

8. Flexibility of the neck domain enhances Kinesin-1 motility under load.

9. Backsteps induced by nucleotide analogs suggest the front head of kinesin is gated by strain.

10. Carboxypeptidase E cytoplasmic tail-driven vesicle transport is key for activity-dependent secretion of peptide hormones.