| Literature DB >> 9851927 |
A Rambukkana1, H Yamada, G Zanazzi, T Mathus, J L Salzer, P D Yurchenco, K P Campbell, V A Fischetti.
Abstract
alpha-Dystroglycan (alpha-DG) is a component of the dystroglycan complex, which is involved in early development and morphogenesis and in the pathogenesis of muscular dystrophies. Here, alpha-DG was shown to serve as a Schwann cell receptor for Mycobacterium leprae, the causative organism of leprosy. Mycobacterium leprae specifically bound to alpha-DG only in the presence of the G domain of the alpha2 chain of laminin-2. Native alpha-DG competitively inhibited the laminin-2-mediated M. leprae binding to primary Schwann cells. Thus, M. leprae may use linkage between the extracellular matrix and cytoskeleton through laminin-2 and alpha-DG for its interaction with Schwann cells.Entities:
Mesh：
Substances：
Year: 1998 PMID： 9851927 DOI： 10.1126/science.282.5396.2076
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728