Literature DB >> 9851926

Promotion of trophoblast stem cell proliferation by FGF4.

S Tanaka1, T Kunath, A K Hadjantonakis, A Nagy, J Rossant.   

Abstract

The trophoblast cell lineage is essential for the survival of the mammalian embryo in utero. This lineage is specified before implantation into the uterus and is restricted to form the fetal portion of the placenta. A culture of mouse blastocysts or early postimplantation trophoblasts in the presence of fibroblast growth factor 4 (FGF4) permitted the isolation of permanent trophoblast stem cell lines. These cell lines differentiated to other trophoblast subtypes in vitro in the absence of FGF4 and exclusively contributed to the trophoblast lineage in vivo in chimeras.

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Year:  1998        PMID： 9851926     DOI： 10.1126/science.282.5396.2072

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  465 in total

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