Literature DB >> 9849870

Cloning and functional characterisation of the mouse P2X7 receptor.

I P Chessell1, J Simon, A D Hibell, A D Michel, E A Barnard, P P Humphrey.   

Abstract

We have isolated a 1785-bp complementary DNA (cDNA) encoding the murine P2X7 receptor subunit from NTW8 mouse microglial cells. The encoded protein has 80%, and 85% homology to the human and rat P2X7 subunits, respectively. Functional properties of the heterologously expressed murine P2X7 homomeric receptor broadly resembled those of the P2X7 receptor in the native cell line. However, marked phenotypic differences were observed between the mouse receptor, and the other P2X7 receptor orthologues isolated with respect to agonist and antagonist potencies, and the kinetics of formation of the large aqueous pore.

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Year:  1998        PMID： 9849870     DOI： 10.1016/s0014-5793(98)01332-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  48 in total

1.  Serum constituents can affect 2'-& 3'-O-(4-benzoylbenzoyl)-ATP potency at P2X(7) receptors.

Authors:  A D Michel; M Xing; P P Humphrey
Journal:  Br J Pharmacol       Date:  2001-04       Impact factor: 8.739

2.  Apparent species differences in the kinetic properties of P2X(7) receptors.

Authors:  A D Hibell; E J Kidd; I P Chessell; P P Humphrey; A D Michel
Journal:  Br J Pharmacol       Date:  2000-05       Impact factor: 8.739

3.  ATP-induced [Ca(2+)](i) changes and depolarization in GH3 cells.

Authors:  H S Chung; K S Park; S K Cha; I D Kong; J W Lee
Journal:  Br J Pharmacol       Date:  2000-08       Impact factor: 8.739

Review 4.  Molecular and functional properties of P2X receptors--recent progress and persisting challenges.

Authors:  Karina Kaczmarek-Hájek; Eva Lörinczi; Ralf Hausmann; Annette Nicke
Journal:  Purinergic Signal       Date:  2012-05-01       Impact factor: 3.765

5.  Large-conductance channel formation mediated by P2X7 receptor activation is regulated through distinct intracellular signaling pathways in peritoneal macrophages and 2BH4 cells.

Authors:  R X Faria; C M Cascabulho; R A M Reis; Luiz Anastácio Alves
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-05-28       Impact factor: 3.000

6.  Identification of Thr283 as a key determinant of P2X7 receptor function.

Authors:  M T Young; P Pelegrin; A Surprenant
Journal:  Br J Pharmacol       Date:  2006-08-29       Impact factor: 8.739

Review 7.  Pharmacology of P2X channels.

Authors:  Joel R Gever; Debra A Cockayne; Michael P Dillon; Geoffrey Burnstock; Anthony P D W Ford
Journal:  Pflugers Arch       Date:  2006-04-29       Impact factor: 3.657

8.  Cloning and pharmacological characterization of the guinea pig P2X7 receptor orthologue.

Authors:  E Fonfria; W C Clay; D S Levy; J A Goodwin; S Roman; G D Smith; J P Condreay; A D Michel
Journal:  Br J Pharmacol       Date:  2007-11-26       Impact factor: 8.739

9.  Functionalized congeners of tyrosine-based P2X(7) receptor antagonists: probing multiple sites for linking and dimerization.

Authors:  Wangzhong Chen; R Gnana Ravi; Sylvia B Kertesy; George R Dubyak; Kenneth A Jacobson
Journal:  Bioconjug Chem       Date:  2002 Sep-Oct       Impact factor: 4.774

10.  P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control.

Authors:  Tobias Engel; Alba Jimenez-Pacheco; Maria Teresa Miras-Portugal; Miguel Diaz-Hernandez; David C Henshall
Journal:  Int J Physiol Pathophysiol Pharmacol       Date:  2012-12-26
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