| Literature DB >> 9849799 |
H Harada1, A Tamaoka, M Watanabe, K Ishikawa, S Shoji.
Abstract
We report two siblings with spinocerebellar ataxia type 6 (SCA 6), both showing downbeat nystagmus (DBN) as a predominant clinical feature. Familial hemiplegic migraine (FHM), episodic ataxia type 2 (EA-2) and SCA 6 are allelic disorders, and interestingly, the occasional presence of DBN in EA-2 was reported. Our observations suggest that common molecular mechanisms might underlie DBN in FHM, EA-2 and SCA 6. Then, these disorders should be kept in mind in diagnosing patients with DBN.Entities:
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Year: 1998 PMID： 9849799 DOI： 10.1016/s0022-510x(98)00250-0
Source DB: PubMed Journal: J Neurol Sci ISSN： 0022-510X Impact factor: 3.181