Literature DB >> 984754

Pharmacokinetic parameters of sisomicin.

B R Meyers, S Z Hirschman, S Yancovitz, B Ribner.   

Abstract

Sisomicin in doses of 1 mg/kg was administered intramuscularly to 10 healthy volunteers, and 1 week later the same volunteers received sisomicin at the same dose intravenously. A peak serum concentration of sisomicin of 3.08 mug/ml was obtained 1 h after intramuscular injection, and a peak serum concentration of 7.12 mug/ml was achieved 30 min after a 30-min intravenous infusion. The sisomicin elimination data were analyzed according to a two-compartment model. Pharmacokinetic parameters derived from the intramuscular and intravenous studies were quite similar.

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Year:  1976        PMID： 984754      PMCID： PMC429683          DOI： 10.1128/AAC.10.1.25

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  10 in total

1.  Drug therapy. Clinical Pharmacokinetics (first of two parts).

Authors:  D J Greenblatt; J Kock-Weser
Journal:  N Engl J Med       Date:  1975-10-02       Impact factor: 91.245

2.  Clinical pharmacology of sisomicin.

Authors:  V Rodriguez; G P Bodey; M Valdivieso; R Feld
Journal:  Antimicrob Agents Chemother       Date:  1975-01       Impact factor: 5.191

3.  Gram-negative rod bacteremia.

Authors:  C M Martin; A J Cuomo; M J Geraghty; J R Zager; T C Mandes
Journal:  J Infect Dis       Date:  1969 Apr-May       Impact factor: 5.226

4.  Pharmacologic studies on tobramycin and comparison with gentamicin.

Authors:  B R Meyers; S Z Hirschman
Journal:  J Clin Pharmacol New Drugs       Date:  1972 Aug-Sep

5.  Comparative pharmacokinetics of tobramycin and gentamicin.

Authors:  C Regamey; R C Gordon; W M Kirby
Journal:  Clin Pharmacol Ther       Date:  1973 May-Jun       Impact factor: 6.875

6.  Assessment of pharmacokinetic constants from postinfusion blood curves obtained after I.V. infusion.

Authors:  J C Loo; S Riegelman
Journal:  J Pharm Sci       Date:  1970-01       Impact factor: 3.534

7.  Antibiotic 6640, a new Micromonospora-produced aminoglycoside antibiotic.

Authors:  M J Weinstein; J A Marquez; R T Testa; G H Wagman; E M Oden; J A Waitz
Journal:  J Antibiot (Tokyo)       Date:  1970-11       Impact factor: 2.649

8.  [Comparative clinical pharmacology of gentamicin, sisomicin, and tobramycin].

Authors:  H Lode; B Kemmerich; P Koeppe
Journal:  Antimicrob Agents Chemother       Date:  1975-10       Impact factor: 5.191

9.  Comparison of the antibacterial activities of sisomicin and gentamicin against gram-negative bacteria.

Authors:  B R Meyers; B Leng; S Z Hirschman
Journal:  Antimicrob Agents Chemother       Date:  1975-12       Impact factor: 5.191

10.  Pharmacokinetics of gentamicin in children and adults.

Authors:  G R Siber; P Echeverria; A L Smith; J W Paisley; D H Smith
Journal:  J Infect Dis       Date:  1975-12       Impact factor: 5.226
  10 in total
  7 in total

1.  Drug kinetics and artificial kidneys.

Authors:  T B Gibson; H A Nelson
Journal:  Clin Pharmacokinet       Date:  1977 Nov-Dec       Impact factor: 6.447

2.  Pharmacokinetic study of netilmicin.

Authors:  B R Meyers; S Z Hirschman; G Wormser; D Siegel
Journal:  Antimicrob Agents Chemother       Date:  1977-07       Impact factor: 5.191

Review 3.  Clinical pharmacokinetics of aminoglycoside antibiotics.

Authors:  J C Pechere; R Dugal
Journal:  Clin Pharmacokinet       Date:  1979 May-Jun       Impact factor: 6.447

4.  Crossover study of the pharmacokinetics of ceftriaxone administered intravenously or intramuscularly to healthy volunteers.

Authors:  B R Meyers; E S Srulevitch; J Jacobson; S Z Hirschman
Journal:  Antimicrob Agents Chemother       Date:  1983-11       Impact factor: 5.191

5.  Pharmacokinetic study of sisomicin in humans.

Authors:  M Chung; J J Schrogie; S Symchowicz
Journal:  J Pharmacokinet Biopharm       Date:  1981-10

6.  Clinico-pharmacological studies of sisomicin in ill children.

Authors:  M I Marks; A Vose; S Hammerberg; R Dugal
Journal:  Antimicrob Agents Chemother       Date:  1978-05       Impact factor: 5.191

7.  Comparative distribution of gentamicin, tobramycin, sisomicin, netilmicin, and amikacin in interstitial fluid in rabbits.

Authors:  C Carbon; A Contrepois; S Lamotte-Barrillon
Journal:  Antimicrob Agents Chemother       Date:  1978-03       Impact factor: 5.191
  7 in total

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