Literature DB >> 9847381

Nuclear magnetic resonance analysis of solution conformations in C4-V3 hybrid peptides derived from human immunodeficiency virus (HIV) type 1 gp120: relation to specificity of peptide-induced anti-HIV neutralizing antibodies.

H M Vu1, D Myers, R de Lorimier, T J Matthews, M A Moody, C Heinly, J V Torres, B F Haynes, L Spicer.   

Abstract

Immunogenic peptides containing epitopes of the gp120 C4 and V3 regions from human immunodeficiency virus strains MN and EV91 have been studied by nuclear magnetic resonance and molecular modeling and used as immunogens in rhesus monkeys. The results, combined with those for other peptides, suggest a correlation between solution conformation and immunologic cross-reactivity.

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Year:  1999        PMID： 9847381      PMCID： PMC103882          DOI： 10.1128/JVI.73.1.746-750.1999

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  31 in total

1.  Induction of broadly cross-reactive cytotoxic T cells recognizing an HIV-1 envelope determinant.

Authors:  H Takahashi; Y Nakagawa; C D Pendleton; R A Houghten; K Yokomuro; R N Germain; J A Berzofsky
Journal:  Science       Date:  1992-01-17       Impact factor: 47.728

2.  Solution conformation of a peptide corresponding to the principal neutralizing determinant of HIV-1IIIB: a two-dimensional NMR study.

Authors:  A Zvi; R Hiller; J Anglister
Journal:  Biochemistry       Date:  1992-08-04       Impact factor: 3.162

3.  Priming of anti-human immunodeficiency virus (HIV) CD8+ cytotoxic T cells in vivo by carrier-free HIV synthetic peptides.

Authors:  M K Hart; K J Weinhold; R M Scearce; E M Washburn; C A Clark; T J Palker; B F Haynes
Journal:  Proc Natl Acad Sci U S A       Date:  1991-11-01       Impact factor: 11.205

Review 4.  Defining solution conformations of small linear peptides.

Authors:  H J Dyson; P E Wright
Journal:  Annu Rev Biophys Biophys Chem       Date:  1991

5.  The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2.

Authors:  D R Madden; D N Garboczi; D C Wiley
Journal:  Cell       Date:  1993-11-19       Impact factor: 41.582

6.  Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen.

Authors:  J M Rini; R L Stanfield; E A Stura; P A Salinas; A T Profy; I A Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-07-01       Impact factor: 11.205

7.  Synthetic peptide in mineral oil adjuvant elicits simian immunodeficiency virus-specific CD8+ cytotoxic T lymphocytes in rhesus monkeys.

Authors:  Y Yasutomi; T J Palker; M B Gardner; B F Haynes; N L Letvin
Journal:  J Immunol       Date:  1993-11-01       Impact factor: 5.422

8.  Induction of HIVMN neutralizing antibodies in primates using a prime-boost regimen of hybrid synthetic gp120 envelope peptides.

Authors:  B F Haynes; J V Torres; A J Langlois; D P Bolognesi; M B Gardner; T J Palker; R M Scearce; D M Jones; M A Moody; C McDanal
Journal:  J Immunol       Date:  1993-08-01       Impact factor: 5.422

9.  Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1.

Authors:  S S Hwang; T J Boyle; H K Lyerly; B R Cullen
Journal:  Science       Date:  1991-07-05       Impact factor: 47.728

10.  Relationship between nuclear magnetic resonance chemical shift and protein secondary structure.

Authors:  D S Wishart; B D Sykes; F M Richards
Journal:  J Mol Biol       Date:  1991-11-20       Impact factor: 5.469
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  3 in total

1.  Induction of antibodies in guinea pigs and rhesus monkeys against the human immunodeficiency virus type 1 envelope: neutralization of nonpathogenic and pathogenic primary isolate simian/human immunodeficiency virus strains.

Authors:  H X Liao; B Etemad-Moghadam; D C Montefiori; Y Sun; J Sodroski; R M Scearce; R W Doms; J R Thomasch; S Robinson; N L Letvin; B F Haynes
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

2.  Probing hydrogen bonds in the antibody-bound HIV-1 gp120 V3 loop by solid state NMR REDOR measurements.

Authors:  J J Balbach; J Yang; D P Weliky; P J Steinbach; V Tugarinov; J Anglister; R Tycko
Journal:  J Biomol NMR       Date:  2000-04       Impact factor: 2.835

3.  Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity.

Authors:  Robyn L Stanfield; Miroslaw K Gorny; Susan Zolla-Pazner; Ian A Wilson
Journal:  J Virol       Date:  2006-06       Impact factor: 5.103
  3 in total

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