Literature DB >> 9845346

Transcellular regulation of cell respiration by nitric oxide generated by activated macrophages.

G C Brown1, N Foxwell, S Moncada.   

Abstract

A macrophage cell line (J774), activated with interferon-gamma and endotoxin to express the inducible form of NO synthase (iNOS), immediately inhibited the cellular respiration of co-incubated L-929 fibroblasts or non-activated J774 macrophages. The inhibition was potent, rapid and reversible when the NO was removed by adding oxyhaemoglobin or by inhibiting iNOS. Exogenously added NO also rapidly and reversibly inhibited cellular respiration over the same range of NO concentrations. This inhibition was competitive with oxygen and due to direct inhibition of cytochrome oxidase. Thus, NO generated by one cell can regulate the respiration of adjacent cells, supporting the hypothesis that NO may be a physiological and/or pathological regulator of cellular respiration, via its inhibition of cytochrome oxidase.

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Year:  1998        PMID： 9845346     DOI： 10.1016/s0014-5793(98)01404-5

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

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5.  Comparative effects of several therapatic agents on hepatic damage induced by acute experimental pancreatitis.

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9.  Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFNgamma-dependent iNOS expression in the vasculature of healthy mice.

Authors:  Jonathan Morton; Barbara Coles; Kate Wright; Awen Gallimore; Jason D Morrow; Erin S Terry; Peter B Anning; B Paul Morgan; Vincent Dioszeghy; Hartmut Kühn; Pavlos Chaitidis; Adrian J Hobbs; Simon A Jones; Valerie B O'Donnell
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  9 in total

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