Literature DB >> 9843996

The akt kinase: molecular determinants of oncogenicity.

M Aoki1, O Batista, A Bellacosa, P Tsichlis, P K Vogt.   

Abstract

The serine-threonine kinase Akt is a downstream target of phosphoinositide 3-kinase (PI 3-kinase); it is activated by the phosphoinositide 3-phosphate-dependent kinases PDK1 and PDK2. Certain mutated forms of Akt induce oncogenic transformation in chicken embryo fibroblast cultures and hemangiosarcomas in young chickens. This ability to transform cells depends on localization of Akt at the plasma membrane and on the kinase activity of Akt. A transdominant negative form of Akt interferes with oncogenic transformation induced by the p3k oncogene, which codes for an activated form of PI 3-kinase. Akt is therefore an essential mediator of p3k-induced oncogenicity.

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Year:  1998        PMID： 9843996      PMCID： PMC24556          DOI： 10.1073/pnas.95.25.14950

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  45 in total

1.  Germline mutations in the PTEN/MMAC1 gene in patients with Cowden disease.

Authors:  M R Nelen; W C van Staveren; E A Peeters; M B Hassel; R J Gorlin; H Hamm; C F Lindboe; J P Fryns; R H Sijmons; D G Woods; E C Mariman; G W Padberg; H Kremer
Journal:  Hum Mol Genet       Date:  1997-08       Impact factor: 6.150

2.  Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery.

Authors:  S R Datta; H Dudek; X Tao; S Masters; H Fu; Y Gotoh; M E Greenberg
Journal:  Cell       Date:  1997-10-17       Impact factor: 41.582

3.  Protein kinase B/Akt is activated by polyomavirus middle-T antigen via a phosphatidylinositol 3-kinase-dependent mechanism.

Authors:  R Meili; P Cron; B A Hemmings; K Ballmer-Hofer
Journal:  Oncogene       Date:  1998-02-19       Impact factor: 9.867

4.  Further evidence that the inhibition of glycogen synthase kinase-3beta by IGF-1 is mediated by PDK1/PKB-induced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216.

Authors:  M Shaw; P Cohen; D R Alessi
Journal:  FEBS Lett       Date:  1997-10-27       Impact factor: 4.124

5.  Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.

Authors:  L del Peso; M González-García; C Page; R Herrera; G Nuñez
Journal:  Science       Date:  1997-10-24       Impact factor: 47.728

6.  Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor.

Authors:  D K Moscatello; M Holgado-Madruga; D R Emlet; R B Montgomery; A J Wong
Journal:  J Biol Chem       Date:  1998-01-02       Impact factor: 5.157

7.  Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B.

Authors:  L Stephens; K Anderson; D Stokoe; H Erdjument-Bromage; G F Painter; A B Holmes; P R Gaffney; C B Reese; F McCormick; P Tempst; J Coadwell; P T Hawkins
Journal:  Science       Date:  1998-01-30       Impact factor: 47.728

8.  Deletion of PTEN in a patient with Bannayan-Riley-Ruvalcaba syndrome suggests allelism with Cowden disease.

Authors:  E M Arch; B K Goodman; R A Van Wesep; D Liaw; K Clarke; R Parsons; V A McKusick; M T Geraghty
Journal:  Am J Med Genet       Date:  1997-09-05

9.  Role of translocation in the activation and function of protein kinase B.

Authors:  M Andjelković; D R Alessi; R Meier; A Fernandez; N J Lamb; M Frech; P Cron; P Cohen; J M Lucocq; B A Hemmings
Journal:  J Biol Chem       Date:  1997-12-12       Impact factor: 5.157

10.  3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase.

Authors:  D R Alessi; M Deak; A Casamayor; F B Caudwell; N Morrice; D G Norman; P Gaffney; C B Reese; C N MacDougall; D Harbison; A Ashworth; M Bownes
Journal:  Curr Biol       Date:  1997-10-01       Impact factor: 10.834
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  101 in total

1.  v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation.

Authors:  T Akagi; T Shishido; K Murata; H Hanafusa
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-20       Impact factor: 11.205

2.  Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

Authors:  N Nakamura; S Ramaswamy; F Vazquez; S Signoretti; M Loda; W R Sellers
Journal:  Mol Cell Biol       Date:  2000-12       Impact factor: 4.272

3.  Restricted 12p amplification and RAS mutation in human germ cell tumors of the adult testis.

Authors:  H Roelofs; M C Mostert; K Pompe; G Zafarana; M van Oorschot; R J van Gurp; A J Gillis; H Stoop; B Beverloo; J W Oosterhuis; C Bokemeyer; L H Looijenga
Journal:  Am J Pathol       Date:  2000-10       Impact factor: 4.307

4.  ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable mutant mice.

Authors:  J L Smith; A E Schaffner; J K Hofmeister; M Hartman; G Wei; D Forsthoefel; D A Hume; M C Ostrowski
Journal:  Mol Cell Biol       Date:  2000-11       Impact factor: 4.272

5.  Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage.

Authors:  Eugene S Kandel; Jennifer Skeen; Nathan Majewski; Antonio Di Cristofano; Pier Paolo Pandolfi; Claudine S Feliciano; Andrei Gartel; Nissim Hay
Journal:  Mol Cell Biol       Date:  2002-11       Impact factor: 4.272

6.  Dissection of the c-Kit signaling pathway in mouse primordial germ cells by retroviral-mediated gene transfer.

Authors:  Maria P De Miguel; Linzhao Cheng; Eric C Holland; Mark J Federspiel; Peter J Donovan
Journal:  Proc Natl Acad Sci U S A       Date:  2002-07-24       Impact factor: 11.205

7.  Proteasomal degradation of the FoxO1 transcriptional regulator in cells transformed by the P3k and Akt oncoproteins.

Authors:  Masahiro Aoki; Hao Jiang; Peter K Vogt
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-01       Impact factor: 11.205

8.  Inhibition of protein synthesis by Y box-binding protein 1 blocks oncogenic cell transformation.

Authors:  Andreas G Bader; Peter K Vogt
Journal:  Mol Cell Biol       Date:  2005-03       Impact factor: 4.272

9.  Akt/PKB interacts with the histone H3 methyltransferase SETDB1 and coordinates to silence gene expression.

Authors:  Haidong Gao; Zhigang Yu; Dongsong Bi; Liyu Jiang; Yazhou Cui; Jingzhong Sun; Rong Ma
Journal:  Mol Cell Biochem       Date:  2007-06-19       Impact factor: 3.396

10.  Evidence of mTOR Activation by an AKT-Independent Mechanism Provides Support for the Combined Treatment of PTEN-Deficient Prostate Tumors with mTOR and AKT Inhibitors.

Authors:  Weisheng Zhang; Brian B Haines; Clay Efferson; Joe Zhu; Chris Ware; Kaiko Kunii; Jennifer Tammam; Minilik Angagaw; Marlene C Hinton; Heike Keilhack; Cloud P Paweletz; Theresa Zhang; Chris Winter; Sriram Sathyanarayanan; Jonathan Cheng; Leigh Zawel; Stephen Fawell; Gary Gilliland; Pradip K Majumder
Journal:  Transl Oncol       Date:  2012-12-01       Impact factor: 4.243
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