OBJECTIVE: The authors' goal was to compare the thalamic, total brain, and intracranial volumes of patients with schizophrenia, their healthy siblings, and normal comparison subjects. METHOD: Magnetic resonance imaging (MRI) brain scans were obtained for 32 same-sex siblings who were discordant for schizophrenia and 32 matched normal comparison subjects. RESULTS: Mean total thalamic volume, corrected for total brain volume, was significantly different among affected siblings, unaffected siblings, and comparison subjects. Thalamic volume was smallest in the patients; thalamic volume in their siblings was smaller than that of comparison subjects but larger than that of the patients with schizophrenia. CONCLUSIONS: These results suggest that healthy siblings of patients with schizophrenia partially share the thalamic abnormalities of their affected relatives.
OBJECTIVE: The authors' goal was to compare the thalamic, total brain, and intracranial volumes of patients with schizophrenia, their healthy siblings, and normal comparison subjects. METHOD: Magnetic resonance imaging (MRI) brain scans were obtained for 32 same-sex siblings who were discordant for schizophrenia and 32 matched normal comparison subjects. RESULTS: Mean total thalamic volume, corrected for total brain volume, was significantly different among affected siblings, unaffected siblings, and comparison subjects. Thalamic volume was smallest in the patients; thalamic volume in their siblings was smaller than that of comparison subjects but larger than that of the patients with schizophrenia. CONCLUSIONS: These results suggest that healthy siblings of patients with schizophrenia partially share the thalamic abnormalities of their affected relatives.
Authors: Elisabeth A Wilde; Stephen R McCauley; Zili Chu; Jill V Hunter; Erin D Bigler; Ragini Yallampalli; Zhiyue J Wang; Gerri Hanten; Xiaoqi Li; Marco A Ramos; Sharjeel H Sabir; Ana C Vasquez; Deleene Menefee; Harvey S Levin Journal: J Clin Exp Neuropsychol Date: 2008-12-03 Impact factor: 2.475
Authors: Matcheri S Keshavan; Shreedhar Kulkarni; Tejas Bhojraj; Alan Francis; Vaibhav Diwadkar; Debra M Montrose; Larry J Seidman; John Sweeney Journal: Front Hum Neurosci Date: 2010-03-09 Impact factor: 3.169