Literature DB >> 9842647

L-asparaginase (Leunase) induced pancreatitis in childhood acute lymphoblastic leukemia.

S Sahu1, S Saika, S K Pai, S H Advani.   

Abstract

A major complication of L-asparaginase therapy in acute lymphoblastic leukemia (ALL) is pancreatitis. Among the 915 cases of ALL seen over last 10 years, 19 (2%) developed pancreatitis. Median age was 5.5 years with a median duration of symptoms of 4 weeks. All cases had raised serum amylase and lipase. Pancreatitis was not related to the dose/duration of L-asparaginase therapy. Ultrasonography can be used as a corroborative investigation for diagnosis along with serum chemistries. Close clinical monitoring of children for early diagnosis of this complication is recommended.

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Year:  1998        PMID： 9842647     DOI： 10.3109/08880019809018315

Source DB:  PubMed          Journal:  Pediatr Hematol Oncol        ISSN： 0888-0018            Impact factor:   1.969


  7 in total

1.  Identification of functional regions in the Rhodospirillum rubrum L-asparaginase by site-directed mutagenesis.

Authors:  M V Pokrovskaya; S S Aleksandrova; V S Pokrovsky; A V Veselovsky; D V Grishin; O Yu Abakumova; O V Podobed; A A Mishin; D D Zhdanov; N N Sokolov
Journal:  Mol Biotechnol       Date:  2015-03       Impact factor: 2.695

2.  A pilot study evaluating changes in pancreatic lipase immunoreactivity concentrations in canines treated with L-asparaginase (ASNase), vincristine, or both for lymphoma.

Authors:  Zachary Wright; Joerg Steiner; Jan Suchodolski; Kenita Rogers; Claudia Barton; Marjorie Brown
Journal:  Can J Vet Res       Date:  2009-04       Impact factor: 1.310

3.  Early diagnosis of asparaginase-associated pancreatitis based on elevated serum elastase-1 levels: Case reports.

Authors:  Tsuyoshi Morimoto; Kota Hirai; Akiko Fukumura; Hiromitsu Takakura; Takashi Koike; Takashi Shimizu
Journal:  Biomed Rep       Date:  2013-05-17

4.  L-asparaginase-induced pancreatic injury is associated with an imbalance in plasma amino acid levels.

Authors:  Kei Minowa; Mitsuyoshi Suzuki; Junya Fujimura; Masahiro Saito; Katsuyoshi Koh; Akira Kikuchi; Ryoji Hanada; Toshiaki Shimizu
Journal:  Drugs R D       Date:  2012-06-01

5.  Acute Pancreatitis and Diabetic Ketoacidosis following L-Asparaginase/Prednisone Therapy in Acute Lymphoblastic Leukemia.

Authors:  Dania Lizet Quintanilla-Flores; Miguel Ángel Flores-Caballero; René Rodríguez-Gutiérrez; Héctor Eloy Tamez-Pérez; José Gerardo González-González
Journal:  Case Rep Oncol Med       Date:  2014-02-10

6.  Concurrent diabetic ketoacidosis and pancreatitis in Paediatric acute lymphoblastic leukemia receiving L-asparaginase.

Authors:  Patel Zeeshan Jameel; Sham Lohiya; Amol Dongre; Sachin Damke; Bhavana B Lakhkar
Journal:  BMC Pediatr       Date:  2020-05-18       Impact factor: 2.125

7.  Asparaginase-Associated Pancreatitis in Acute Lymphoblastic Leukemia: Results From the NOPHO ALL2008 Treatment of Patients 1-45 Years of Age.

Authors:  Cecilie U Rank; Benjamin O Wolthers; Kathrine Grell; Birgitte K Albertsen; Thomas L Frandsen; Ulrik M Overgaard; Nina Toft; Ove J Nielsen; Peder S Wehner; Arja Harila-Saari; Mats M Heyman; Johan Malmros; Jonas Abrahamsson; Ulrika Norén-Nyström; Beata Tomaszewska-Toporska; Bendik Lund; Kirsten B Jarvis; Petter Quist-Paulsen; Goda E Vaitkevičienė; Laimonas Griškevičius; Mervi Taskinen; Ulla Wartiovaara-Kautto; Kristi Lepik; Mari Punab; Ólafur G Jónsson; Kjeld Schmiegelow
Journal:  J Clin Oncol       Date:  2019-11-26       Impact factor: 44.544
  7 in total

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