Literature DB >> 98419

Effect of alrestatin on arginine-induced secretion of glucagon and insulin in the rat.

W Lippmann, M Kobric.   

Abstract

Alrestatin, a lens aldose reductase inhibitor, decreased i.v. arginine-induced glucagon levels and augmented arginine-stimulated insulin release in the ether anesthetized rat. Alrestatin may then be useful in the treatment of diabetes mellitus, due to its actions on insulin and glucagon, and its capacity to delay the onset of sugar-induced cataracts in the rat.

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Year:  1978        PMID： 98419     DOI： 10.1055/s-0028-1093414

Source DB:  PubMed          Journal:  Horm Metab Res        ISSN： 0018-5043            Impact factor:   2.936


  3 in total

1.  Enzymes in pancreatic islets that use NADP(H) as a cofactor including evidence for a plasma membrane aldehyde reductase.

Authors:  M Laclau; F Lu; M J MacDonald
Journal:  Mol Cell Biochem       Date:  2001-09       Impact factor: 3.396

2.  The effect of alrestatin on alanine-stimulated release of insulin and glucagon in man.

Authors:  L A Distiller; B I Joffe; M Sandler; A Kark; H C Seftel
Journal:  J Endocrinol Invest       Date:  1981 Jan-Mar       Impact factor: 4.256

Review 3.  Physiological and Pathological Roles of Aldose Reductase.

Authors:  Mahavir Singh; Aniruddh Kapoor; Aruni Bhatnagar
Journal:  Metabolites       Date:  2021-09-27
  3 in total

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