Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Estimation of age and rate of increase of rare variants.

Literature DB >> 984040

Estimation of age and rate of increase of rare variants.

Abstract

The problem considered is that of estimating the age or rate of increase of a variant on the basis of the present number of replicates observed in a population. In place of previous diffusion equation analyses of age probability distributions, the likelihood for the age is studied on the basis of a discrete branching process model. It is shown that variations inherent in the process of gene evolution in natural populations make it impossible to provide a reliable point estimate of the age of a specified variant, although the likelihood analysis provides a confidence interval which may place useful bounds on the period in which a variant originated. The observed distribution of numbers of several variants may also provide useful information. The problems of estimation are discussed with reference to rare variants arising in American Indian populations.

Mesh：

Year: 1976 PMID： 984040 PMCID： PMC1685108

Source DB: PubMed Journal: Am J Hum Genet ISSN： 0002-9297 Impact factor: 11.025

9 in total

1. The Average Number of Generations until Fixation of a Mutant Gene in a Finite Population.

Authors: M Kimura; T Ohta
Journal: Genetics Date: 1969-03 Impact factor: 4.562

2. The age of a rare mutant gene in a large population.

Authors: T Maruyama
Journal: Am J Hum Genet Date: 1974-11 Impact factor: 11.025

3. "Private" genetic variants and the frequency of mutation among South American Indians.

Authors: J V Neel
Journal: Proc Natl Acad Sci U S A Date: 1973-12 Impact factor: 11.205

4. Maximum-likelihood estimation of evolutionary trees from continuous characters.

Authors: J Felsenstein
Journal: Am J Hum Genet Date: 1973-09 Impact factor: 11.025

5. Total number of individuals affected by a single deleterious mutation in a finite population.

Authors: W H Li; M Nei
Journal: Am J Hum Genet Date: 1972-11 Impact factor: 11.025

6. Demographic structure of a primitive population: a simulation.

Authors: J W MacCluer; J V Neel; N A Chagnon
Journal: Am J Phys Anthropol Date: 1971-09 Impact factor: 2.868

7. The demography of two tribes of primitive, relatively unacculturated American Indians.

Authors: J V Neel; N A Chagnon
Journal: Proc Natl Acad Sci U S A Date: 1968-03 Impact factor: 11.205

8. The first arrival time and mean age of a deleterious mutant gene in a finite population.

Authors: W H Li
Journal: Am J Hum Genet Date: 1975-05 Impact factor: 11.025

9. The genetic structure of a tribal population, the Yanomama Indians. XII. Biodemographic studies.

Authors: J V Neel; K M Weiss
Journal: Am J Phys Anthropol Date: 1975-01 Impact factor: 2.868

9 in total

8 in total

8. Origin and spread of the 1278insTATC mutation causing Tay-Sachs disease in Ashkenazi Jews: genetic drift as a robust and parsimonious hypothesis.

Authors: Amos Frisch; Roberto Colombo; Elena Michaelovsky; Mazal Karpati; Boleslaw Goldman; Leah Peleg
Journal: Hum Genet Date: 2004-01-15 Impact factor: 4.132

8 in total

Estimation of age and rate of increase of rare variants.

1. The Average Number of Generations until Fixation of a Mutant Gene in a Finite Population.

2. The age of a rare mutant gene in a large population.

3. "Private" genetic variants and the frequency of mutation among South American Indians.

4. Maximum-likelihood estimation of evolutionary trees from continuous characters.

5. Total number of individuals affected by a single deleterious mutation in a finite population.

6. Demographic structure of a primitive population: a simulation.

7. The demography of two tribes of primitive, relatively unacculturated American Indians.

8. The first arrival time and mean age of a deleterious mutant gene in a finite population.

9. The genetic structure of a tribal population, the Yanomama Indians. XII. Biodemographic studies.

1. Microevolution of the Chibcha-speaking peoples of lower Central America: rare genes in an Amerindian complex.

2. Mitochondrial DNA "clock" for the Amerinds and its implications for timing their entry into North America.

3. Estimating the age of alleles by use of intraallelic variability.

4. Dating rare mutations from small samples with dense marker data.

5. Probability of founder effect in a tribal population.

6. Protein variants in Hiroshima and Nagasaki: tales of two cities.

7. Indirect estimates of mutation rates in tribal Amerindians.

8. Origin and spread of the 1278insTATC mutation causing Tay-Sachs disease in Ashkenazi Jews: genetic drift as a robust and parsimonious hypothesis.