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Literature DB >> 9839696

Effects of lipoxygenase metabolites of arachidonic acid on the growth of human mononuclear marrow cells and marrow stromal cell cultures.

V Desplat¹, F Dupuis, F Trimoreau, C Dulery, V Praloran, Y Denizot.

Abstract

The effects of various lipoxygenase metabolites of arachidonic acid (AA) were investigated on the growth of freshly isolated human bone marrow mononuclear cells and marrow stromal cell cultures. LTB4, LXA4, LXB4, 12-HETE and 15-HETE (1 microM) decreased [3H]-thymidine incorporation on marrow stromal cell cultures without affecting cell number. Only 12-HETE showed a dose-response effect on [3H]-thymidine incorporation. While LTB4 (1 microM) decreased thymidine incorporation on marrow mononuclear cells, LTC4, LXA4, LXB4, 12-HETE and 15-HETE had no effect. The lipoxygenase inhibitor NDGA had no effect on both cell types suggesting no role of endogenous lipoxygenase metabolites on cell growth. These results suggest no important role of lipoxygenase metabolites of AA on the proliferation of human marrow mononuclear cells and marrow stromal cell cultures.

Entities: Chemical Species

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Year: 1998 PMID： 9839696 PMCID： PMC1781818 DOI： 10.1080/09629359891351

Source DB: PubMed Journal: Mediators Inflamm ISSN： 0962-9351 Impact factor: 4.711

18 in total

1. Evidence for the role of leukotrienes C4 and D4 as essential intermediates in CSF-stimulated human myeloid colony formation.

Authors: A M Miller; R S Weiner; V A Ziboh
Journal: Exp Hematol Date: 1986-09 Impact factor: 3.084

2. Lipoxygenase metabolites of arachidonic acid modulate hematopoiesis.

Authors: D S Snyder; J F Desforges
Journal: Blood Date: 1986-06 Impact factor: 22.113

3. Leukotriene production by fresh human bone marrow cells: evidence of altered lipoxygenase activity in chronic myelocytic leukemia.

Authors: L Stenke; L Laurén; P Reizenstein; J A Lindgren
Journal: Exp Hematol Date: 1987-02 Impact factor: 3.084

4. PAF and hematopoiesis. VIII. Biosynthesis and metabolism of PAF by human bone marrow stromal cells.

Authors: Y Denizot; F Rougier; F Dupuis; C Verger; C Dulery; M Laskar; J C Aldigier; V Praloran
Journal: Exp Hematol Date: 1996-09 Impact factor: 3.084

5. Platelet-activating factor and antagonists modulate DNA synthesis in human bone marrow stromal cell cultures.

Authors: F Rougier; F Dupuis; E Cornu; C Dulery; V Praloran; Y Denizot
Journal: J Lipid Mediat Cell Signal Date: 1997-07

Review 6. Human bone marrow fibroblasts--an overview of their characterization, proliferation and inflammatory mediator production.

Authors: F Rougier; F Dupuis; Y Denizot
Journal: Hematol Cell Ther Date: 1996-07

Effects of lipoxygenase metabolites of arachidonic acid on the growth of human mononuclear marrow cells and marrow stromal cell cultures.

1. Evidence for the role of leukotrienes C4 and D4 as essential intermediates in CSF-stimulated human myeloid colony formation.

2. Lipoxygenase metabolites of arachidonic acid modulate hematopoiesis.

3. Leukotriene production by fresh human bone marrow cells: evidence of altered lipoxygenase activity in chronic myelocytic leukemia.

4. PAF and hematopoiesis. VIII. Biosynthesis and metabolism of PAF by human bone marrow stromal cells.

5. Platelet-activating factor and antagonists modulate DNA synthesis in human bone marrow stromal cell cultures.

Review 6. Human bone marrow fibroblasts--an overview of their characterization, proliferation and inflammatory mediator production.

7. Spontaneous and inducible production of macrophage colony-stimulating factor by human bone marrow stromal cells.

8. Eicosanoid effects on cell proliferation in vitro: relevance to atherosclerosis.

9. Stimulation of human myelopoiesis by leukotriene B4.

10. Inhibition of human malignant neuroblastoma cell DNA synthesis by lipoxygenase metabolites of arachidonic acid.

1. Arachidonic acid and freshly isolated human bone marrow mononuclear cells.

2. Incorporation and effect of arachidonic acid on the growth of human myeloma cell lines.