Literature DB >> 9839019

Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part II: Mechanism-based inhibition of rat liver microsome-mediated aflatoxin B1-DNA binding by the candidate antimutagen 7,8-diacetoxy-4-methylcoumarin.

H G Raj1, V S Parmar, S C Jain, S Goel, A Singh, K Gupta, V Rohil, Y K Tyagi, H N Jha, C E Olsen, J Wengel.   

Abstract

7,8-Diacetoxy-4-methylcoumarin (DAMC), with no prerequisite for oxidative biotransformation has been reported to produce suicide inactivation of microsomal cytochrome P-450-catalysed formation of aflatoxin B1-8,9-oxide that binds to DNA. Parenteral administration of DAMC to rats caused significant inhibition of AFB1 binding to hepatic DNA in vivo as well as AFB1-induced micronuclei formation in bone marrow cells. These results highlight the antimutagenic potential of DAMC.

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Year:  1998        PMID： 9839019     DOI： 10.1016/s0968-0896(98)00111-4

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  6 in total

1.  Novel coumarin-based tyrosinase inhibitors discovered by OECD principles-validated QSAR approach from an enlarged, balanced database.

Authors:  Huong Le-Thi-Thu; Gerardo M Casañola-Martín; Yovani Marrero-Ponce; Antonio Rescigno; Luciano Saso; Virinder S Parmar; Francisco Torrens; Concepción Abad
Journal:  Mol Divers       Date:  2010-09-03       Impact factor: 2.943

2.  In vitro evaluation of 3-arylcoumarin derivatives in A549 cell line.

Authors:  Musiliyu A Musa; Moise Y Joseph; Lekan M Latinwo; Veera Badisa; John S Cooperwood
Journal:  Anticancer Res       Date:  2015-02       Impact factor: 2.480

3.  Cytotoxic activity of new acetoxycoumarin derivatives in cancer cell lines.

Authors:  Musiliyu A Musa; Veera L D Badisa; Lekan M Latinwo; John Cooperwood; Andre Sinclair; Ahkinyala Abdullah
Journal:  Anticancer Res       Date:  2011-06       Impact factor: 2.480

4.  Site-directed mutagenesis in the P-domain of calreticulin transacylase identifies Lys-207 as the active site residue.

Authors:  Rini Joshi; Prabhjot Singh; Naresh K Sharma; Prija Ponnan; Daman Saluja; Jasvinder K Gambhir; Diwan S Rawat; Virinder S Parmar; Bilkere S Dwarakanath; Ashok K Prasad; Hanumantharao G Raj
Journal:  3 Biotech       Date:  2021-02-03       Impact factor: 2.406

Review 5.  Comparison of protein acetyltransferase action of CRTAase with the prototypes of HAT.

Authors:  Prija Ponnan; Ajit Kumar; Prabhjot Singh; Prachi Gupta; Rini Joshi; Marco Gaspari; Luciano Saso; Ashok K Prasad; Ramesh C Rastogi; Virinder S Parmar; Hanumantharao G Raj
Journal:  ScientificWorldJournal       Date:  2014-02-04

6.  6-7-Dimethoxy-4-methylcoumarin suppresses pro-inflammatory mediator expression through inactivation of the NF-κB and MAPK pathways in LPS-induced RAW 264.7 cells.

Authors:  Kil-Nam Kim; Hye-Won Yang; Seok-Chun Ko; Yeong-Jong Ko; Eun-A Kim; Seong Woon Roh; Eun-Yi Ko; Ginnae Ahn; Soo-Jin Heo; You-Jin Jeon; Weon-Jong Yoon; Chang-Gu Hyun; Daekyung Kim
Journal:  EXCLI J       Date:  2014-07-21       Impact factor: 4.068
  6 in total

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