| Literature DB >> 9838180 |
N M Strangman1, S L Patrick, A G Hohmann, K Tsou, J M Walker.
Abstract
The competitive CB1 receptor antagonist SR141716A was used to test the hypothesis that endogenous cannabinoids modulate tonic pain sensitivity. Pretreatment with the antagonist significantly enhanced the response to a chemical nociceptive stimulus in the formalin test. Postreatment with the antagonist 5 min following the induction of tonic pain produced hyperalgesia during the tonic phase only. These findings suggest that endogenous cannabinoids serve naturally to modulate the maintenance of pain following repeated noxious stimulation. Copyright 1998 Elsevier Science B.V.Entities:
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Year: 1998 PMID： 9838180 DOI： 10.1016/s0006-8993(98)01031-2
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252