Literature DB >> 9838126

Absence of antinociceptive tolerance to improgan, a cimetidine analog, in rats.

M D Bannoura1, J W Nalwalk, Y Tang, M Carlile, R Leurs, W M Menge, H Timmerman, L B Hough.   

Abstract

Improgan, an analog of the histamine receptor antagonist cimetidine, produces highly effective analgesia following intraventricular injection. The present study examined changes in the antinociceptive effects of improgan following once daily intraventricular injections. Improgan (100-150 microg) produced near maximal antinociception 10 and 30 min after daily administration on all 4 test days, whereas comparable morphine treatments (50 microg) induced considerable tolerance. Thus, improgan produced highly effective analgesia without the development of tolerance. Copyright 1998 Elsevier Science B.V.

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Year:  1998        PMID： 9838126     DOI： 10.1016/s0006-8993(98)01024-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  4 in total

1.  Neural basis for improgan antinociception.

Authors:  M M Heinricher; M E Martenson; J W Nalwalk; L B Hough
Journal:  Neuroscience       Date:  2010-05-24       Impact factor: 3.590

2.  Antinociceptive activity of CC44, a biotinylated improgan congener.

Authors:  Paul Hoerbelt; Julia W Nalwalk; James G Phillips; Mark P Wentland; Zhixing Shan; Lindsay B Hough
Journal:  Eur J Pharmacol       Date:  2013-07-05       Impact factor: 4.432

3.  Improgan-induced hypothermia: a role for cannabinoid receptors in improgan-induced changes in nociceptive threshold and body temperature.

Authors:  Catherine L Salussolia; Julia W Nalwalk; Lindsay B Hough
Journal:  Brain Res       Date:  2007-03-15       Impact factor: 3.252

4.  Inhibition of brain [(3)H]cimetidine binding by improgan-like antinociceptive drugs.

Authors:  Rebecca Stadel; Amanda B Carpenter; Julia W Nalwalk; Iwan J P de Esch; Elwin Janssen; Lindsay B Hough
Journal:  Eur J Pharmacol       Date:  2010-02-06       Impact factor: 4.432
  4 in total

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