Literature DB >> 9836641

dMi-2, a hunchback-interacting protein that functions in polycomb repression.

J Kehle1, D Beuchle, S Treuheit, B Christen, J A Kennison, M Bienz, J Müller.   

Abstract

Early in Drosophila embryogenesis, gap gene products directly repress transcription of homeotic (HOX) genes and thereby delimit HOX expression domains. Subsequently, Polycomb-group proteins maintain this repression. Currently, there is no known molecular link between gap and Polycomb-group proteins. Here, dMi-2 is identified as a protein that binds to a domain in the gap protein Hunchback that is specifically required for the repression of HOX genes. Genetic analyses show that dMi-2 participates in both Hunchback and Polycomb repression in vivo. Hence, recruitment of dMi-2 may serve as a link between repression of HOX genes by Hunchback and Polycomb proteins.

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Year:  1998        PMID： 9836641     DOI： 10.1126/science.282.5395.1897

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  119 in total

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Review 4.  ATP-dependent chromatin-remodeling complexes.

Authors:  M Vignali; A H Hassan; K E Neely; J L Workman
Journal:  Mol Cell Biol       Date:  2000-03       Impact factor: 4.272

5.  CoREST is an integral component of the CoREST- human histone deacetylase complex.

Authors:  A You; J K Tong; C M Grozinger; S L Schreiber
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-13       Impact factor: 11.205

6.  Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2alpha subunit of NuRD.

Authors:  D C Schultz; J R Friedman; F J Rauscher
Journal:  Genes Dev       Date:  2001-02-15       Impact factor: 11.361

7.  Mutations in the FIE and MEA genes that encode interacting polycomb proteins cause parent-of-origin effects on seed development by distinct mechanisms.

Authors:  R Yadegari; T Kinoshita; O Lotan; G Cohen; A Katz; Y Choi; A Katz; K Nakashima; J J Harada; R B Goldberg; R L Fischer; N Ohad
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Review 8.  DNA methylation and histone deacetylation in the control of gene expression: basic biochemistry to human development and disease.

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Journal:  Gene Expr       Date:  2000

9.  Chromosomal localization links the SIN3-RPD3 complex to the regulation of chromatin condensation, histone acetylation and gene expression.

Authors:  L A Pile; D A Wassarman
Journal:  EMBO J       Date:  2000-11-15       Impact factor: 11.598

Review 10.  Above and within the genome: epigenetics past and present.

Authors:  F D Urnov; A P Wolffe
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