Literature DB >> 9836639

KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.

H S Wang1, Z Pan, W Shi, B S Brown, R S Wymore, I S Cohen, J E Dixon, D McKinnon.   

Abstract

The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.

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Year:  1998        PMID： 9836639     DOI： 10.1126/science.282.5395.1890

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  477 in total

1.  Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells.

Authors:  A D Wickenden; A Zou; P K Wagoner; T Jegla
Journal:  Br J Pharmacol       Date:  2001-01       Impact factor: 8.739

2.  Delayed rectifier currents in rat globus pallidus neurons are attributable to Kv2.1 and Kv3.1/3.2 K(+) channels.

Authors:  G Baranauskas; T Tkatch; D J Surmeier
Journal:  J Neurosci       Date:  1999-08-01       Impact factor: 6.167

3.  Two types of K(+) channel subunit, Erg1 and KCNQ2/3, contribute to the M-like current in a mammalian neuronal cell.

Authors:  A A Selyanko; J K Hadley; I C Wood; F C Abogadie; P Delmas; N J Buckley; B London; D A Brown
Journal:  J Neurosci       Date:  1999-09-15       Impact factor: 6.167

4.  12-Lipoxygenase overexpression in rodent NG108-15 cells enhances membrane excitability by inhibiting M-type K+ channels.

Authors:  Y Takahashi; H Kawajiri; T Yoshimoto; N Hoshi; H Higashida
Journal:  J Physiol       Date:  1999-12-15       Impact factor: 5.182

5.  Inhibition of KCNQ1-4 potassium channels expressed in mammalian cells via M1 muscarinic acetylcholine receptors.

Authors:  A A Selyanko; J K Hadley; I C Wood; F C Abogadie; T J Jentsch; D A Brown
Journal:  J Physiol       Date:  2000-02-01       Impact factor: 5.182

Review 6.  Molecular basis of functional voltage-gated K+ channel diversity in the mammalian myocardium.

Authors:  J M Nerbonne
Journal:  J Physiol       Date:  2000-06-01       Impact factor: 5.182

7.  Reconstitution of muscarinic modulation of the KCNQ2/KCNQ3 K(+) channels that underlie the neuronal M current.

Authors:  M S Shapiro; J P Roche; E J Kaftan; H Cruzblanca; K Mackie; B Hille
Journal:  J Neurosci       Date:  2000-03-01       Impact factor: 6.167

8.  M-channel gating and simulation.

Authors:  A A Selyanko; D A Brown
Journal:  Biophys J       Date:  1999-08       Impact factor: 4.033

9.  Electrophysiological characterization of voltage-gated K(+) currents in cerebellar basket and purkinje cells: Kv1 and Kv3 channel subfamilies are present in basket cell nerve terminals.

Authors:  A P Southan; B Robertson
Journal:  J Neurosci       Date:  2000-01-01       Impact factor: 6.167

10.  Alternative splicing of KCNQ2 potassium channel transcripts contributes to the functional diversity of M-currents.

Authors:  Z Pan; A A Selyanko; J K Hadley; D A Brown; J E Dixon; D McKinnon
Journal:  J Physiol       Date:  2001-03-01       Impact factor: 5.182
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