Literature DB >> 9836499

Immunomodulating activities of a natural alpha1-acid glycoprotein and its carbohydrate chains attached to the protein-free polymer.

A L Pukhalsky1, S D Shyian, E A Kalashnikova, G V Shmarina, D A Pukhalskaya, N V Bovin.   

Abstract

Immunomodulating effects of a neoglycoconjugate created on the basis of alpha1-acid glycoprotein (AGP) carbohydrate chains and synthetic protein-free carrier have been investigated. It was demonstrated that this pseudo-AGP suppressed PHA- or anti-CD3 antibody-induced lymphocyte proliferation in a dose-dependent manner. Pseudo-AGP revealed a similar antiproliferative effect as the natural AGP samples. Stimulation of the LPS-induced proinflammatory cytokine production by mononuclear cells treated with both natural and pseudo-AGP has been also demonstrated. These data show that carbohydrate chains of AGP play a crucial role in the studied biological effect realization.

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Year:  1998        PMID： 9836499      PMCID： PMC1781831          DOI： 10.1080/09629359891270

Source DB:  PubMed          Journal:  Mediators Inflamm        ISSN： 0962-9351            Impact factor:   4.711


  14 in total

1.  [Effect of glycoforms of alpha1-acid glycoprotein on in vitro production of tumor necrosis factor and interleukin-1 by mononuclear leukocytes from human peripheral blood].

Authors:  A L Pukhal'skiĭ; E A Kalashnikova; S D Shiian; N V Bovin
Journal:  Biull Eksp Biol Med       Date:  1998-01

2.  Human alpha 1-acid glycoprotein-exposed macrophages release interleukin 1 inhibitory activity.

Authors:  P N Bories; M Guenounou; J Féger; E Kodari; J Agneray; G Durand
Journal:  Biochem Biophys Res Commun       Date:  1987-09-15       Impact factor: 3.575

3.  Synthesis of polymeric neoglycoconjugates based on N-substituted polyacrylamides.

Authors:  N V Bovin; T V Zemlyanukhina; N E Byramova; O E Galanina; A E Zemlyakov; A E Ivanov; V P Zubov; L V Mochalova
Journal:  Glycoconj J       Date:  1993-04       Impact factor: 2.916

4.  Prevalence of tri- and tetraantennary glycans of human alpha 1-acid glycoprotein in release of macrophage inhibitor of interleukin-1 activity.

Authors:  P N Bories; J Feger; N Benbernou; J D Rouzeau; J Agneray; G Durand
Journal:  Inflammation       Date:  1990-06       Impact factor: 4.092

5.  [Molecular forms of alpha-1-acid glycoprotein in human blood serum. Differences in levels of di-, tri-, and tetra-antennary N-linked carbohydrate chains].

Authors:  S D Shiian; V V Nasonov; N V Bovin; L I Novikova; V A Aleshkin
Journal:  Bioorg Khim       Date:  1991-05

6.  Alpha 1-acid glycoprotein potentiates lipopolysaccharide-induced secretion of interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha by human monocytes and alveolar and peritoneal macrophages.

Authors:  A Boutten; M Dehoux; M Deschenes; J D Rouzeau; P N Bories; G Durand
Journal:  Eur J Immunol       Date:  1992-10       Impact factor: 5.532

7.  [The production and characteristics of an interleukin-6-dependent hybridoma].

Authors:  E N Kliushnenkova; V V Malaĭtseva
Journal:  Biull Eksp Biol Med       Date:  1992-07

8.  Con A-nonreactive human alpha 1-acid glycoprotein (AGP) is more effective in modulation of lymphocyte proliferation than Con A-reactive AGP serum variants.

Authors:  O Pos; R A Oostendorp; M E van der Stelt; R J Scheper; W Van Dijk
Journal:  Inflammation       Date:  1990-04       Impact factor: 4.092

9.  Glycosylation of three molecular forms of human alpha 1-acid glycoprotein having different interactions with concanavalin A. Variations in the occurrence of di-, tri-, and tetraantennary glycans and the degree of sialylation.

Authors:  M F Bierhuizen; M De Wit; C A Govers; W Ferwerda; C Koeleman; O Pos; W Van Dijk
Journal:  Eur J Biochem       Date:  1988-08-01

10.  Immunosuppression by human plasma alpha 1-acid glycoprotein: importance of the carbohydrate moiety.

Authors:  M Bennett; K Schmid
Journal:  Proc Natl Acad Sci U S A       Date:  1980-10       Impact factor: 11.205
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