INTRODUCTION: Although thromboembolism is an uncommon complication of radiofrequency (RF) ablation, some preliminary reports have suggested that RF ablation results in activation of the coagulation system, possibly increasing this risk. We hypothesized that the insertion of intravenous catheters and their prolonged intravenous placement rather than RF ablation activates the coagulation cascade. METHODS AND RESULTS: Thirty-seven patients, group 1 (n = 21) during RF ablation, and group 2 (n = 16) during routine electrophysiologic studies (EPS), were studied prospectively. Blood was drawn for coagulation and fibrinolytic studies following insertion of venous sheaths (T0), following catheter placement (T1), and 1 hour after completion of RF ablation or EPS (T2). Conversion of prothrombin to thrombin was measured using thrombin-antithrombin complex (TAT) and prothrombin activation peptide (F1+2), and fibrinolytic activity was assessed using D-dimer concentration. Levels of D-dimer increased in group 1 from 823.52+/-323.52 ng/mL at T0 to 1,314.28+/-297.63 ng/mL at T2 (P = 0.005), and in group 2 from 658.15+/-161.70 ng/mL at T0 to 1625+/-641.45 ng/mL at T2 (P = 0.064). TAT levels increased from to 27.74+/-5.6 microg/L at T0 to 52.99+/-5.93 microg/L at T2 in group 1 (P = 0.09), and from 19.79+/-5.14 microg/L at T0 to 73.5+/-24.15 microg/L at T2 in group 2 (P = 0.05). F1+2 concentration increased from 1.52+/-0.30 nmol/L at T0 to 3.06+/-0.41 nmol/L at T2 in group 1 (P = 0.004), and from 1.32+/-0.30 nmol/L at T0 to 3.11+/-0.46 nmol/L at T2 in group 2 (P = 0.087). There was no significant difference in the concentration of the three coagulation variables between group 1 and group 2 at any given time point. No correlation was demonstrable between concentration of D-dimers, TAT, or F1+2 and variables of RF delivery such as cumulative energy, number of RF energy applications, or number of impedance rises. However, a significant positive correlation (r = 0.65, P<0.01) was noted between the duration of the RF ablation procedure and the concentration of D-dimers. CONCLUSION: We conclude that activation of the coagulation cascade in RF ablation procedures is not related to the delivery of RF energy, but is related to the placement of intravascular catheters and to the duration of the ablation procedure.
INTRODUCTION: Although thromboembolism is an uncommon complication of radiofrequency (RF) ablation, some preliminary reports have suggested that RF ablation results in activation of the coagulation system, possibly increasing this risk. We hypothesized that the insertion of intravenous catheters and their prolonged intravenous placement rather than RF ablation activates the coagulation cascade. METHODS AND RESULTS: Thirty-seven patients, group 1 (n = 21) during RF ablation, and group 2 (n = 16) during routine electrophysiologic studies (EPS), were studied prospectively. Blood was drawn for coagulation and fibrinolytic studies following insertion of venous sheaths (T0), following catheter placement (T1), and 1 hour after completion of RF ablation or EPS (T2). Conversion of prothrombin to thrombin was measured using thrombin-antithrombin complex (TAT) and prothrombin activation peptide (F1+2), and fibrinolytic activity was assessed using D-dimer concentration. Levels of D-dimer increased in group 1 from 823.52+/-323.52 ng/mL at T0 to 1,314.28+/-297.63 ng/mL at T2 (P = 0.005), and in group 2 from 658.15+/-161.70 ng/mL at T0 to 1625+/-641.45 ng/mL at T2 (P = 0.064). TAT levels increased from to 27.74+/-5.6 microg/L at T0 to 52.99+/-5.93 microg/L at T2 in group 1 (P = 0.09), and from 19.79+/-5.14 microg/L at T0 to 73.5+/-24.15 microg/L at T2 in group 2 (P = 0.05). F1+2 concentration increased from 1.52+/-0.30 nmol/L at T0 to 3.06+/-0.41 nmol/L at T2 in group 1 (P = 0.004), and from 1.32+/-0.30 nmol/L at T0 to 3.11+/-0.46 nmol/L at T2 in group 2 (P = 0.087). There was no significant difference in the concentration of the three coagulation variables between group 1 and group 2 at any given time point. No correlation was demonstrable between concentration of D-dimers, TAT, or F1+2 and variables of RF delivery such as cumulative energy, number of RF energy applications, or number of impedance rises. However, a significant positive correlation (r = 0.65, P<0.01) was noted between the duration of the RF ablation procedure and the concentration of D-dimers. CONCLUSION: We conclude that activation of the coagulation cascade in RF ablation procedures is not related to the delivery of RF energy, but is related to the placement of intravascular catheters and to the duration of the ablation procedure.
Authors: Min Dai; Tao Jiang; Cai-Dong Luo; Wei Du; Min Wang; Qing-Yan Qiu; Hu Wang Journal: J Interv Card Electrophysiol Date: 2022-07-21 Impact factor: 1.759
Authors: Alan Bulava; Ludek Slavík; Martin Fiala; Petr Heinc; Marcela Skvarilova; Jan Lukl; Vera Krcová; Karel Indrák Journal: J Interv Card Electrophysiol Date: 2004-06 Impact factor: 1.900
Authors: Mohamed Bassiouny; Walid Saliba; John Rickard; Mingyuan Shao; Albert Sey; Mariam Diab; David O Martin; Ayman Hussein; Maurice Khoury; Bernard Abi-Saleh; Samir Alam; Jay Sengupta; P Peter Borek; Bryan Baranowski; Mark Niebauer; Thomas Callahan; Niraj Varma; Mina Chung; Patrick J Tchou; Mohamed Kanj; Thomas Dresing; Bruce D Lindsay; Oussama Wazni Journal: Circ Arrhythm Electrophysiol Date: 2013-04-03