| Literature DB >> 9834149 |
S S Lee1, W C Chen, C F Huang, Y Su.
Abstract
Six ceanothane and 1-norceanothane derivatives (1, 2, 8-11) were prepared from ceanothic acid dibenzyl ester. These ring-A homologues of betulinic acid exhibited cytotoxic effects. Among these, 1-decarboxy-3-oxo-ceanothic acid (2) was found to be the most cytotoxic against OVCAR-3 and HeLa cancer cell lines, with an IC50 of 2.8 and 6.6 microg/mL, respectively, and an IC50 of 11.3 microg/mL against normal cell line FS-5.Entities:
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Year: 1998 PMID： 9834149 DOI： 10.1021/np9800856
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050