| Literature DB >> 9834145 |
M J O'Neill1, J A Lewis, H M Noble, S Holland, C Mansat, J E Farthing, G Foster, D Noble, S J Lane, P J Sidebottom, S M Lynn, M V Hayes, C J Dix.
Abstract
Methanolic extracts prepared from the leaves of Lantana camara have been found to inhibit human thrombin. An assay, in which thrombin activity is measured as a function of clot formation from fibrinogen, was used to guide the fractionation and purification of five principal active constituents (1-5), which were all characterized as 5,5-trans-fused cyclic lactone-containing euphane triterpenes.Entities:
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Year: 1998 PMID： 9834145 DOI： 10.1021/np970464j
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050