Literature DB >> 9831287

Endocannabinoids.

R Mechoulam1, E Fride, V Di Marzo.   

Abstract

The background knowledge leading to the isolation and identification of anandamide and 2-arachidonoyl glycerol, the principal endocannabinoids is described. The structure-activity relationships of these lipid derivatives are summarized. Selected biochemical and pharmacological topics in this field are discussed, the main ones being levels of endocannabinoids in unstimulated tissue and cells, biosynthesis, release and inactivation of endocannabinoids, the effects of 'entourage' compounds on the activities of anandamide and 2-arachidonoyl glycerol, their signaling mechanisms and effects in animals.

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Year:  1998        PMID： 9831287     DOI： 10.1016/s0014-2999(98)00649-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  114 in total

1.  Anandamide and diet: inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets.

Authors:  A Berger; G Crozier; T Bisogno; P Cavaliere; S Innis; V Di Marzo
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-15       Impact factor: 11.205

2.  Anandamide reduces infarct size in rat isolated hearts subjected to ischaemia-reperfusion by a novel cannabinoid mechanism.

Authors:  Nichola J Underdown; C Robin Hiley; William R Ford
Journal:  Br J Pharmacol       Date:  2005-11       Impact factor: 8.739

3.  Depolarization-induced retrograde synaptic inhibition in the mouse cerebellar cortex is mediated by 2-arachidonoylglycerol.

Authors:  Bela Szabo; Michal J Urbanski; Tiziana Bisogno; Vincenzo Di Marzo; Aitziber Mendiguren; Wolfram U Baer; Ilka Freiman
Journal:  J Physiol       Date:  2006-09-14       Impact factor: 5.182

4.  Tempo and mode in the endocannaboinoid system.

Authors:  John M McPartland; Ryan W Norris; C William Kilpatrick
Journal:  J Mol Evol       Date:  2007-08-04       Impact factor: 2.395

5.  CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration.

Authors:  M Rajesh; P Mukhopadhyay; G Haskó; J W Huffman; K Mackie; P Pacher
Journal:  Br J Pharmacol       Date:  2007-11-12       Impact factor: 8.739

Review 6.  Antiinflammatory and neuroprotective actions of COX2 inhibitors in the injured brain.

Authors:  Kenneth I Strauss
Journal:  Brain Behav Immun       Date:  2007-11-08       Impact factor: 7.217

7.  Cannabinoids selectively inhibit proliferation and induce death of cultured human glioblastoma multiforme cells.

Authors:  Sean D McAllister; Calvin Chan; Ryan J Taft; Tri Luu; Mary E Abood; Dan H Moore; Ken Aldape; Garret Yount
Journal:  J Neurooncol       Date:  2005-08       Impact factor: 4.130

8.  Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice.

Authors:  Lei Wang; Jie Liu; Judith Harvey-White; Andreas Zimmer; George Kunos
Journal:  Proc Natl Acad Sci U S A       Date:  2003-01-21       Impact factor: 11.205

9.  Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy.

Authors:  Partha Mukhopadhyay; Mohanraj Rajesh; Hao Pan; Vivek Patel; Bani Mukhopadhyay; Sándor Bátkai; Bin Gao; György Haskó; Pál Pacher
Journal:  Free Radic Biol Med       Date:  2009-12-04       Impact factor: 7.376

Review 10.  The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities.

Authors:  Tamás Bíró; Balázs I Tóth; György Haskó; Ralf Paus; Pál Pacher
Journal:  Trends Pharmacol Sci       Date:  2009-07-14       Impact factor: 14.819
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