Synaptic PDZ domain-containing proteins.

Synaptic junctions accumulate various molecules involved in neurotransmissions and synaptic plasticity. The proper organizations of these molecules at synaptic junctions sustain the interneuronal signal transmissions and the subsequent signal cascades underling learning and memory. Recent studies have revealed that a protein-interacting module named a PDZ domain plays important roles in the interactions among the components of synaptic junctions. In this article, we summarize synaptic PDZ domain-containing proteins and discussed their functions.