Literature DB >> 9829945

Methionine induces sexual development in the fission yeast Schizosaccharomyces pombe via an ste11-dependent signalling pathway.

A M Schweingruber1, N Hilti, E Edenharter, M E Schweingruber.   

Abstract

Methionine added to minimal medium overcomes the repressing effects of ammonium and cyclic AMP (cAMP) on sexual development and efficiently induces mating and sporulation in homothallic strains of Schizosaccharomyces pombe. In heterothallic strains it induces G1 arrest when cells enter stationary phase. We show that methionine reduces the intracellular cAMP pool and induces the expression of at least two cAMP-repressible genes, including fbp1 and ste11. The easiest interpretation of the results is that methionine induces sexual development via a cAMP-dependent ste11 signalling pathway.

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Year:  1998        PMID： 9829945      PMCID： PMC107721          DOI： 10.1128/JB.180.23.6338-6341.1998

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  16 in total

1.  Isolation and characterization of regulatory mutants from Schizosaccharomyces pombe involved in thiamine-regulated gene expression.

Authors:  A M Schweingruber; H Fankhauser; J Dlugonski; C Steinmann-Loss; M E Schweingruber
Journal:  Genetics       Date:  1992-03       Impact factor: 4.562

2.  Exogenous inositol and genes responsible for inositol transport are required for mating and sporulation in Shizosaccharomyces pombe.

Authors:  C Niederberger; R Gräub; A M Schweingruber; H Fankhauser; M Rusu; M Poitelea; L Edenharter; M E Schweingruber
Journal:  Curr Genet       Date:  1998-04       Impact factor: 3.886

3.  Glucose repression of transcription of the Schizosaccharomyces pombe fbp1 gene occurs by a cAMP signaling pathway.

Authors:  C S Hoffman; F Winston
Journal:  Genes Dev       Date:  1991-04       Impact factor: 11.361

4.  Characterization of a fission yeast gene, gpa2, that encodes a G alpha subunit involved in the monitoring of nutrition.

Authors:  T Isshiki; N Mochizuki; T Maeda; M Yamamoto
Journal:  Genes Dev       Date:  1992-12       Impact factor: 11.361

5.  Thiamine in Schizosaccharomyces pombe: dephosphorylation, intracellular pool, biosynthesis and transport.

Authors:  A M Schweingruber; J Dlugonski; E Edenharter; M E Schweingruber
Journal:  Curr Genet       Date:  1991-04       Impact factor: 3.886

6.  Schizosaccharomyces pombe pac2+ controls the onset of sexual development via a pathway independent of the cAMP cascade.

Authors:  H Kunitomo; A Sugimoto; C R Wilkinson; M Yamamoto
Journal:  Curr Genet       Date:  1995-06       Impact factor: 3.886

7.  Reduction in the intracellular cAMP level triggers initiation of sexual development in fission yeast.

Authors:  N Mochizuki; M Yamamoto
Journal:  Mol Gen Genet       Date:  1992-05

8.  Thiamin regulates agglutination and zygote formation in Schizosaccharomyces pombe.

Authors:  M E Schweingruber; E Edenharter
Journal:  Curr Genet       Date:  1990-03       Impact factor: 3.886

9.  Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein alpha subunit encoded by gpa2 (git8).

Authors:  M Nocero; T Isshiki; M Yamamoto; C S Hoffman
Journal:  Genetics       Date:  1994-09       Impact factor: 4.562

10.  Schizosaccharomyces pombe thiamine pyrophosphokinase is encoded by gene tnr3 and is a regulator of thiamine metabolism, phosphate metabolism, mating, and growth.

Authors:  H Fankhauser; A Zurlinden; A M Schweingruber; E Edenharter; M E Schweingruber
Journal:  J Biol Chem       Date:  1995-11-24       Impact factor: 5.157
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  6 in total

1.  G protein-coupled receptor Gpr4 senses amino acids and activates the cAMP-PKA pathway in Cryptococcus neoformans.

Authors:  Chaoyang Xue; Yong-Sun Bahn; Gary M Cox; Joseph Heitman
Journal:  Mol Biol Cell       Date:  2005-11-16       Impact factor: 4.138

Review 2.  Signal transduction cascades regulating fungal development and virulence.

Authors:  K B Lengeler; R C Davidson; C D'souza; T Harashima; W C Shen; P Wang; X Pan; M Waugh; J Heitman
Journal:  Microbiol Mol Biol Rev       Date:  2000-12       Impact factor: 11.056

3.  A STE12 homolog is required for mating but dispensable for filamentation in candida lusitaniae.

Authors:  L Y Young; M C Lorenz; J Heitman
Journal:  Genetics       Date:  2000-05       Impact factor: 4.562

4.  Cloning the Schizosaccharomyces pombe lys2+ gene and construction of new molecular genetic tools.

Authors:  Richard L Hoffman; Charles S Hoffman
Journal:  Curr Genet       Date:  2006-02-21       Impact factor: 3.886

5.  Functional analysis of the homoserine O-acetyltransferase gene and its identification as a selectable marker in Gibberella zeae.

Authors:  You-Kyoung Han; Theresa Lee; Kap-Hoon Han; Sung-Hwan Yun; Yin-Won Lee
Journal:  Curr Genet       Date:  2004-09-17       Impact factor: 3.886

6.  Promoter nucleosome dynamics regulated by signalling through the CTD code.

Authors:  Philippe Materne; Jayamani Anandhakumar; Valerie Migeot; Ignacio Soriano; Carlo Yague-Sanz; Elena Hidalgo; Carole Mignion; Luis Quintales; Francisco Antequera; Damien Hermand
Journal:  Elife       Date:  2015-06-22       Impact factor: 8.140
  6 in total

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