BACKGROUND AND OBJECTIVE: Knowledge about optical parameters and the resultant light distribution in laser-treated tissue is important for predicting the effects of laser-induced thermotherapy of liver metastases (LITT). MATERIALS AND METHODS: The absorption and scattering coefficients as well as the anisotropy factors and the optical penetration depths of human liver tissue and colorectal liver metastases were determined at 850, 980, and 1,064 nm under native and thermocoagulated conditions. RESULTS: Liver metastases had a lower anisotropy factor, absorption, and scattering coefficient than healthy liver (P < 0.01), resulting in a significantly higher optical penetration depth in metastatic tissue. Coagulation significantly changes the optical parameters by reducing the optical penetration depth in both tissue types (P < 0.01). CONCLUSIONS: A greater optical penetration depth in metastatic tissue is advantageous for LITT, since larger tumor volumes can be coagulated. At the same time, an adjustment of the application parameters during LITT is necessary to achieve optimal therapeutic success.
BACKGROUND AND OBJECTIVE: Knowledge about optical parameters and the resultant light distribution in laser-treated tissue is important for predicting the effects of laser-induced thermotherapy of liver metastases (LITT). MATERIALS AND METHODS: The absorption and scattering coefficients as well as the anisotropy factors and the optical penetration depths of human liver tissue and colorectal liver metastases were determined at 850, 980, and 1,064 nm under native and thermocoagulated conditions. RESULTS:Liver metastases had a lower anisotropy factor, absorption, and scattering coefficient than healthy liver (P < 0.01), resulting in a significantly higher optical penetration depth in metastatic tissue. Coagulation significantly changes the optical parameters by reducing the optical penetration depth in both tissue types (P < 0.01). CONCLUSIONS: A greater optical penetration depth in metastatic tissue is advantageous for LITT, since larger tumor volumes can be coagulated. At the same time, an adjustment of the application parameters during LITT is necessary to achieve optimal therapeutic success.
Authors: Jörg-Peter Ritz; Kai S Lehmann; Thomas Schumann; Verena Knappe; Urte Zurbuchen; Heinz J Buhr; Christoph Holmer Journal: Lasers Med Sci Date: 2011-04-01 Impact factor: 3.161
Authors: Sarah B White; Dong-Hyun Kim; Yang Guo; Weiguo Li; Yihe Yang; Jeane Chen; Venkateswara R Gogineni; Andrew C Larson Journal: Radiology Date: 2017-07-13 Impact factor: 11.105
Authors: Monalisa Jacob Guiselini; Alessandro Melo Deana; Marcelo Betti Mascaro; Aquel Agnelli Mesquita-Ferrari; Ana Carolina Costa da Mota; Sandra Kalil Bussadori; Cristiane Miranda França; Kristianne Porta Santos Fernandes Journal: J Lasers Med Sci Date: 2016-07-18