| Literature DB >> 9824702 |
F R Cagampang1, H D Piggins, W J Sheward, A J Harmar, C W Coen.
Abstract
A receptor for pituitary adenylate cyclase activating polypeptide (PACAP), denoted as PAC1, is expressed in the suprachiasmatic nuclei (SCN). Since the circadian clock demonstrates phase-dependent sensitivity to PACAP, we have used in situ hybridization histochemistry to examine whether PAC1 mRNA is differentially expressed in the rat SCN across the 24-h cycle. There was a significant variation in PAC1 mRNA within the SCN and supraoptic nuclei during the light-dark cycle and in constant darkness, with peaks at the middle of both the real and subjective day and night; no significant variation was observed in the cingulate cortex. The results suggest that the phase-dependent actions of PACAP on the clock may involve phase-specific changes in the availability of PAC1 receptors within the SCN. Copyright 1998 Published by Elsevier Science B.V.Entities:
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Year: 1998 PMID： 9824702 DOI： 10.1016/s0006-8993(98)01044-0
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252