STUDY OBJECTIVE: To determine the efficacy of IV immunoglobulin (IVIg) in severe asthma to reduce steroid requirements. DESIGN: Pre- and posttreatment measurements were analyzed using Dunnett's multiple comparison procedure. SETTING: Hospital clinical research center. PATIENTS: Eleven adolescents and adults with severe, steroid-dependent asthma enrolled over a 14-month period. INTERVENTIONS: IVIg was administered at a dose of 2 g/kg every 4 weeks for a total of seven infusions. MEASUREMENTS AND RESULTS: Steroid requirements, pulmonary function including lung volumes, symptom scores, bone densitometry, and airway reactivity monitored by methacholine challenge were followed over the course of 7 months. A significant decrease in steroid usage was achieved. Despite substantial steroid reduction, the patients demonstrated improvement in their pulmonary function and symptom scores. The responses to methacholine challenge were unaffected by IVIg treatment. CONCLUSIONS: IVIg provides a potentially important adjunctive therapy in severe asthma, reducing oral steroid requirements and steroid side effects without deterioration of lung function.
STUDY OBJECTIVE: To determine the efficacy of IV immunoglobulin (IVIg) in severe asthma to reduce steroid requirements. DESIGN: Pre- and posttreatment measurements were analyzed using Dunnett's multiple comparison procedure. SETTING: Hospital clinical research center. PATIENTS: Eleven adolescents and adults with severe, steroid-dependent asthma enrolled over a 14-month period. INTERVENTIONS: IVIg was administered at a dose of 2 g/kg every 4 weeks for a total of seven infusions. MEASUREMENTS AND RESULTS:Steroid requirements, pulmonary function including lung volumes, symptom scores, bone densitometry, and airway reactivity monitored by methacholine challenge were followed over the course of 7 months. A significant decrease in steroid usage was achieved. Despite substantial steroid reduction, the patients demonstrated improvement in their pulmonary function and symptom scores. The responses to methacholine challenge were unaffected by IVIg treatment. CONCLUSIONS: IVIg provides a potentially important adjunctive therapy in severe asthma, reducing oral steroid requirements and steroid side effects without deterioration of lung function.
Authors: M Yamamoto; K Kobayashi; Y Ishikawa; K Nakata; Y Funada; Y Kotani; A Masuda; T Takai; T Azuma; M Yoshida; Y Nishimura Journal: Clin Exp Immunol Date: 2010-09-01 Impact factor: 4.330
Authors: Joo Hee Kim; Sunghoon Park; Yong Il Hwang; Seung Hun Jang; Ki Suck Jung; Yun Su Sim; Cheol Hong Kim; Changhwan Kim; Dong Gyu Kim Journal: J Korean Med Sci Date: 2016-10 Impact factor: 2.153
Authors: Joo Hee Kim; Young Min Ye; Ga Young Ban; Yoo Seob Shin; Hyun Young Lee; Young Hee Nam; Soo Keol Lee; You Sook Cho; Seung Hun Jang; Ki Suck Jung; Hae Sim Park Journal: Allergy Asthma Immunol Res Date: 2017-11 Impact factor: 5.764