M Gugger1, J O Gebbers. 1. Institute of Pathology, Kantonsspital Luzern, Switzerland.
Abstract
AIMS: To determine the pathogenesis of splenic peliosis by further morphological and immunohistochemical examination. METHODS AND RESULTS: Histological, electron microscopic and immunohistochemical examination revealed evidence for an inflammatory genesis of splenic peliosis with destruction of reticular fibres and local deposits of IgG and activated complement C3. CONCLUSION: Our findings indicate that the peliotic lesion in the spleen may be mediated by immune-complex deposits.
AIMS: To determine the pathogenesis of splenic peliosis by further morphological and immunohistochemical examination. METHODS AND RESULTS: Histological, electron microscopic and immunohistochemical examination revealed evidence for an inflammatory genesis of splenic peliosis with destruction of reticular fibres and local deposits of IgG and activated complement C3. CONCLUSION: Our findings indicate that the peliotic lesion in the spleen may be mediated by immune-complex deposits.