PURPOSE: This study was undertaken to determine what changes, if any, occur in the electroencephalogram (EEG) and in neuropsychological test findings of adults with medically intractable complex partial epilepsy over a 10-year period. METHODS: We studied 35 adults, with a mean age of 32 years (range, 16-59 years) at time of initial testing. We compared the distribution of epileptiform patterns documented on the initial pair of waking and sleeping EEGs to those observed on another pair obtained 10 years later. During this same 10-year period, we also examined changes in the Wechsler Adult Intelligence Scale (WAIS) and on the tests from the Neuropsychological Battery for Epilepsy. RESULTS: The EEGs of 28 (80%) of patients at the tenth year were identical to those seen initially. Five (14%) of patients demonstrated EEGs after 10 years with either no discharges or only unilateral discharges, where bilateral discharges were seen a decade earlier. Only two (6%) of patients had EEGs at the tenth year that showed bilateral discharges where only unilateral discharges were seen originally. We found no general change in intelligence or neuropsychological functioning after 10 years, although a few subtle losses were noted on several neuropsychological measures. CONCLUSIONS: For most adults with medically intractable complex partial epilepsy, the EEG and neuropsychological test scores remain reasonably stable over a decade.
PURPOSE: This study was undertaken to determine what changes, if any, occur in the electroencephalogram (EEG) and in neuropsychological test findings of adults with medically intractable complex partial epilepsy over a 10-year period. METHODS: We studied 35 adults, with a mean age of 32 years (range, 16-59 years) at time of initial testing. We compared the distribution of epileptiform patterns documented on the initial pair of waking and sleeping EEGs to those observed on another pair obtained 10 years later. During this same 10-year period, we also examined changes in the Wechsler Adult Intelligence Scale (WAIS) and on the tests from the Neuropsychological Battery for Epilepsy. RESULTS: The EEGs of 28 (80%) of patients at the tenth year were identical to those seen initially. Five (14%) of patients demonstrated EEGs after 10 years with either no discharges or only unilateral discharges, where bilateral discharges were seen a decade earlier. Only two (6%) of patients had EEGs at the tenth year that showed bilateral discharges where only unilateral discharges were seen originally. We found no general change in intelligence or neuropsychological functioning after 10 years, although a few subtle losses were noted on several neuropsychological measures. CONCLUSIONS: For most adults with medically intractable complex partial epilepsy, the EEG and neuropsychological test scores remain reasonably stable over a decade.
Authors: Emily L Johnson; Gregory L Krauss; Keenan A Walker; Jason Brandt; Anna Kucharska-Newton; Thomas H Mosley; Sevil Yasar; Rebecca F Gottesman Journal: Epilepsia Date: 2020-07-24 Impact factor: 5.864
Authors: Stylianos Gatzonis; Nikolaos Triantafyllou; Maria Kateri; Anna Siatouni; Elias Angelopoulos; Vasilios K Kimiskidis Journal: Neurol Int Date: 2010-11-26
Authors: Alix Warburton; Fabio Miyajima; Kanvel Shazadi; Joanne Crossley; Michael R Johnson; Anthony G Marson; Gus A Baker; John P Quinn; Graeme J Sills Journal: Epilepsy Behav Date: 2015-12-17 Impact factor: 2.937
Authors: Alexandre Ademar Hoeller; Cristiane Ribeiro de Carvalho; Pedro Leite Costa Franco; Douglas Affonso Formolo; Alexandre Kracker Imthon; Henrique Rodighero Dos Santos; Ingrid Eidt; Gabriel Roman Souza; Leandra Celso Constantino; Camila Leite Ferreira; Rui Daniel Prediger; Rodrigo Bainy Leal; Roger Walz Journal: Pharmaceuticals (Basel) Date: 2017-09-13