Literature DB >> 9821392

The mechanism of ceftazidime degradation in aqueous solutions.

M Zajac1, J Siwek, I Muszalska.   

Abstract

Degradation of ceftazidime in aqueous solutions was studied at 298 K in acidic, basic and neutral conditions. The subsequent stage of hydrolysis involved the hydrolysis of the group at C-3, opening of the beta-lactam ring, and epimerization at C-6 or C-7. The decomposition of ceftazidime and the formation and identification of product C (pyridine) was followed by HPLC.

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Year:  1998        PMID： 9821392

Source DB:  PubMed          Journal:  Acta Pol Pharm        ISSN： 0001-6837            Impact factor:   0.330


  3 in total

Review 1.  Systematic review of stability data pertaining to selected antibiotics used for extended infusions in outpatient parenteral antimicrobial therapy (OPAT) at standard room temperature and in warmer climates.

Authors:  Stephen John Perks; Cassie Lanskey; Niechole Robinson; Tilley Pain; Richard Franklin
Journal:  Eur J Hosp Pharm       Date:  2019-06-20

2.  Stability of the combination of ceftazidime and cephazolin in icodextrin or pH neutral peritoneal dialysis solution.

Authors:  Rahul P Patel; Madhur D Shastri; Mohammad Bakkari; Troy Wanandy; Matthew D Jose
Journal:  Perit Dial Int       Date:  2014-01-02       Impact factor: 1.756

3.  Comparative stability studies of antipseudomonal beta-lactams for potential administration through portable elastomeric pumps (home therapy for cystic fibrosis patients) and motor-operated syringes (intensive care units).

Authors:  Eric Viaene; Hugues Chanteux; Hélène Servais; Marie-Paule Mingeot-Leclercq; Paul M Tulkens
Journal:  Antimicrob Agents Chemother       Date:  2002-08       Impact factor: 5.191
  3 in total

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