| Literature DB >> 982064 |
R P Kesner, D J Priano, J R DeWitt.
Abstract
Electroconvulsive shock or frontal cortex stimulation administered to rats at 5 but not at 180 minutes after an initial administration of morphine sulfate disrupted the development of one-trial tolerance to the analgesic effects of morphine sulfate. It is suggested that development of tolerance may be mediated by cellular mechanisms and memory processes similar to those thought to underlie conventional learning.Entities:
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Year: 1976 PMID： 982064 DOI： 10.1126/science.982064
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728