Literature DB >> 982059

Effect of charcoal-broiled beef on phenacetin metabolism in man.

E J Pantuck, K C Hsiao, A H Conney, W A Garland, A Kappas, K E Anderson, A P Alvares.   

Abstract

When charcoal-broiled beef was fed to human volunteers, who were then given phenacetin orally, the concentration of phenacetin in the plasma was lowered, but its half-life in the plasma was not changed. The data suggest that feeding charcoal-broiled beef enhances the metabolism of orally administered phenacetin in the intestine or during its first pass through the liver, or both.

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Year:  1976        PMID: 982059     DOI: 10.1126/science.982059

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  13 in total

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