Literature DB >> 982057

Cannabinoid induced behavioral convulsions in rabbits.

P Martin, P Consroe.   

Abstract

A population of New Zealand White rabbits has been found to exhibit behavioral convulsions when given low intravenous doses of psychoactive cannabinoids of marijuana. The behavioral convulsions decrease in severity and then disappear after the long-term administration of delta9-tetrahydrocannabinol. The extreme sensitivity of these rabbits to the stimulant action of cannabinoids suggests that the population might serve as a model in studies of the stimulant action of cannabinoids.

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Year:  1976        PMID: 982057     DOI: 10.1126/science.982057

Source DB:  PubMed          Journal:  Science        ISSN: 0036-8075            Impact factor:   47.728


  10 in total

Review 1.  "Herbal incense": designer drug blends as cannabimimetics and their assessment by drug discrimination and other in vivo bioassays.

Authors:  Torbjörn U C Järbe; Roger S Gifford
Journal:  Life Sci       Date:  2013-07-25       Impact factor: 5.037

Review 2.  Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders.

Authors:  Orrin Devinsky; Maria Roberta Cilio; Helen Cross; Javier Fernandez-Ruiz; Jacqueline French; Charlotte Hill; Russell Katz; Vincenzo Di Marzo; Didier Jutras-Aswad; William George Notcutt; Jose Martinez-Orgado; Philip J Robson; Brian G Rohrback; Elizabeth Thiele; Benjamin Whalley; Daniel Friedman
Journal:  Epilepsia       Date:  2014-05-22       Impact factor: 5.864

Review 3.  Functional Relevance of Endocannabinoid-Dependent Synaptic Plasticity in the Central Nervous System.

Authors:  Shana M Augustin; David M Lovinger
Journal:  ACS Chem Neurosci       Date:  2018-02-19       Impact factor: 4.418

4.  Slim evidence for cannabinoids for epilepsy.

Authors:  John W Miller
Journal:  Epilepsy Curr       Date:  2013-03       Impact factor: 7.500

Review 5.  Marijuana Use in Epilepsy: The Myth and the Reality.

Authors:  Kamil Detyniecki; Lawrence Hirsch
Journal:  Curr Neurol Neurosci Rep       Date:  2015-10       Impact factor: 5.081

6.  Tolerance to, and symmetrical cross-tolerance between, cannabinol and delta 9-tetrahydrocannabinol.

Authors:  B S Fish; P Consroe
Journal:  Experientia       Date:  1981-03-15

7.  Generalization of the discriminative stimulus properties of delta 9-THC to delta 9(11)-THC in rats.

Authors:  A Semjonow; M Binder
Journal:  Psychopharmacology (Berl)       Date:  1985       Impact factor: 4.530

8.  Cannabidiol Therapy for Refractory Epilepsy and Seizure Disorders.

Authors:  Victoria Golub; D Samba Reddy
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

9.  Excitatory and depressant effects of delta 9-tetrahydrocannabinol and cannabidiol on cortical evoked responses in the conscious rat.

Authors:  S A Turkanis; R Karler
Journal:  Psychopharmacology (Berl)       Date:  1981       Impact factor: 4.530

10.  Subacute cannabinoid treatment: anticonvulsant activity and withdrawal excitability in mice.

Authors:  R Karler; S A Turkanis
Journal:  Br J Pharmacol       Date:  1980-03       Impact factor: 8.739

  10 in total

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