Literature DB >> 982031

Regulation of acetylcholine synthesis: does cytoplasmic acetylcholine control high affinity choline uptake?

D J Jenden, R S Jope, M H Weiler.   

Abstract

When brain synaptosomes are obtained from animals that have been injected intravenously with [2H4]choline 1 minute before being killed, their high affinity [3H] choline uptake is correlated inversely with their acetylcholine content and directly with the rate at which they synthesize [2H4]acetylcholine. The control of such choline uptake by the cytoplasmic acetylcholine concentration is proposed as a mechanism regulating acetylcholine synthesis in cholinergic nerve terminals.

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Year:  1976        PMID： 982031     DOI： 10.1126/science.982031

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  9 in total

1.  Studies on choline transport enhancement into fibroblasts from normals and Alzheimer's donors.

Authors:  L C Mokrasch
Journal:  Neurochem Res       Date:  1991-07       Impact factor: 3.996

2.  Cardiac norepinephrine transporter protein expression is inversely correlated to chamber norepinephrine content.

Authors:  Erica A Wehrwein; Lindsay M Parker; Anna A Wright; John M Spitsbergen; Martin Novotny; Dagmar Babankova; Greg M Swain; Beth A Habecker; David L Kreulen
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2008-06-18       Impact factor: 3.619

3.  Development of behavioral tolerance: a search for subcellular mechanisms.

Authors:  R W Russell; V G Carson; R S Jope; R A Booth; J Macri
Journal:  Psychopharmacology (Berl)       Date:  1979-11       Impact factor: 4.530

4.  Effect of physostigmine and atropine on acetylcholine turnover in mouse brain.

Authors:  B Karlén; G Lundgren; J Lundin; B Holmstedt
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1979-07       Impact factor: 3.000

5.  Acetylcholine metabolism and choline availability at the neuromuscular junction of mature adult and aged rats.

Authors:  D O Smith; M H Weiler
Journal:  J Physiol       Date:  1987-02       Impact factor: 5.182

6.  Changes in synaptosomal high affinity choline uptake following electrical stimulation of guinea-pig cortical slices: effect of atropine and physostigmine.

Authors:  T Antonelli; L Beani; C Bianchi; F Pedata; G Pepeu
Journal:  Br J Pharmacol       Date:  1981-11       Impact factor: 8.739

7.  Effect of the 'antidementia drug' pantoyl-GABA on high affinity transport of choline and on the contents of choline and acetylcholine in rat brain.

Authors:  M Nakahiro; D Mochizuki; S Uchida; H Yoshida
Journal:  Br J Pharmacol       Date:  1988-12       Impact factor: 8.739

8.  MKC-231, a choline uptake enhancer: (3) Mode of action of MKC-231 in the enhancement of high-affinity choline uptake.

Authors:  Ken Takashina; Tomoko Bessho; Reiko Mori; Kunji Kawai; Junichi Eguchi; Ken-Ichi Saito
Journal:  J Neural Transm (Vienna)       Date:  2008-05-07       Impact factor: 3.575

9.  Effects of chronic social defeat stress on behavior and choline acetyltransferase, 78-kDa glucose-regulated protein, and CCAAT/enhancer-binding protein (C/EBP) homologous protein in adult mice.

Authors:  Tong Zhao; Guang-Biao Huang; Sushma Shrestha Muna; Tarique Rajasaheb Bagalkot; Hong-Mei Jin; Han-Jung Chae; Young-Chul Chung
Journal:  Psychopharmacology (Berl)       Date:  2013-03-07       Impact factor: 4.530
  9 in total

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