Literature DB >> 9820130

Leptin changes Ca2+/calmodulin-dependent response and up-regulates the gene expression of calcineurin in rat hypothalamus.

T Morishita1, T Hidaka, K Sugahara, T Noguchi.   

Abstract

To understand the leptin's action on hypothalamic arcuate nucleus (ARC), Ca2+/calmodulin (CaM)-dependent response in leptin-treated rat ARC was investigated. The in vitro phosphorylation of ARC extracts from leptin-treated rats did not respond to CaM. Although CaM-dependent protein kinase II activity was not affected by leptin, the gene expression of calcineurin, CaM-dependent phosphatase, increased in leptin-treated rats.

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Year:  1998        PMID： 9820130     DOI： 10.1016/s0024-3205(98)00460-3

Source DB:  PubMed          Journal:  Life Sci        ISSN： 0024-3205            Impact factor:   5.037


  3 in total

1.  Downregulation of fasting-induced cAMP response element-mediated gene induction by leptin in neuropeptide Y neurons of the arcuate nucleus.

Authors:  M Shimizu-Albergine; D L Ippolito; J A Beavo
Journal:  J Neurosci       Date:  2001-02-15       Impact factor: 6.167

2.  Distribution of CaMKIIα expression in the brain in vivo, studied by CaMKIIα-GFP mice.

Authors:  Xinjun Wang; Chunzhao Zhang; Gábor Szábo; Qian-Quan Sun
Journal:  Brain Res       Date:  2013-04-28       Impact factor: 3.252

3.  Diabetic db/db mice exhibit central nervous system and peripheral molecular alterations as seen in neurological disorders.

Authors:  A Ernst; A N Sharma; K M Elased; P C Guest; H Rahmoune; S Bahn
Journal:  Transl Psychiatry       Date:  2013-05-28       Impact factor: 6.222
  3 in total

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