Literature DB >> 9820032

The VHL tumour-suppressor gene paradigm.

W G Kaelin1, E R Maher.   

Abstract

The VHL tumour-suppressor gene (TSG) has a critical 'gatekeeper' role in regulating growth and differentiation of human kidney cells, and inactivation of the VHL gene is the most frequent genetic event in human kidney cancer. There are many similarities between the genetics of the VHL and retinoblastoma TSGs, but the VHL tumourigenesis model is more complex. Here, we examine the current knowledge of the genetics and functional aspects of the VHL TSG, and emphasize how the VHL gene provides a paradigm that illustrates many aspects of TSG biology.

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Year:  1998        PMID： 9820032     DOI： 10.1016/s0168-9525(98)01558-3

Source DB:  PubMed          Journal:  Trends Genet        ISSN： 0168-9525            Impact factor:   11.639


  47 in total

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2.  VHL: a very hip ligase.

Authors:  M Tyers; R Rottapel
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3.  Identification of multiple CDH1 homologues in vertebrates conferring different substrate specificities.

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Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-30       Impact factor: 11.205

4.  The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation.

Authors:  J G Zhang; A Farley; S E Nicholson; T A Willson; L M Zugaro; R J Simpson; R L Moritz; D Cary; R Richardson; G Hausmann; B T Kile; B J Kile; S B Kent; W S Alexander; D Metcalf; D J Hilton; N A Nicola; M Baca
Journal:  Proc Natl Acad Sci U S A       Date:  1999-03-02       Impact factor: 11.205

5.  The t(1;12)(q21;p13) translocation of human acute myeloblastic leukemia results in a TEL-ARNT fusion.

Authors:  F Salomon-Nguyen; V Della-Valle; M Mauchauffe; M Busson-Le Coniat; J Ghysdael; R Berger; O A Bernard
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

6.  Human kidney injury molecule-1 is a tissue and urinary tumor marker of renal cell carcinoma.

Authors:  Won K Han; Anwar Alinani; Chin-Lee Wu; Dror Michaelson; Massimo Loda; Francis J McGovern; Ravi Thadhani; Joseph V Bonventre
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7.  Transcriptional regulation of serine/threonine kinase-15 (STK15) expression by hypoxia and HIF-1.

Authors:  Alexandra Klein; Daniela Flügel; Thomas Kietzmann
Journal:  Mol Biol Cell       Date:  2008-06-18       Impact factor: 4.138

8.  Analysis of germline variants in CDH1, IGFBP3, MMP1, MMP3, STK15 and VEGF in familial and sporadic renal cell carcinoma.

Authors:  Christopher Ricketts; Maurice P Zeegers; Jan Lubinski; Eamonn R Maher
Journal:  PLoS One       Date:  2009-06-24       Impact factor: 3.240

9.  Molecular targeted therapy in advanced renal cell carcinoma: A review of its recent past and a glimpse into the near future.

Authors:  John S P Yuen
Journal:  Indian J Urol       Date:  2009 Oct-Dec

10.  Ubiquitin/SUMO modification regulates VHL protein stability and nucleocytoplasmic localization.

Authors:  Qiliang Cai; Erle S Robertson
Journal:  PLoS One       Date:  2010-09-09       Impact factor: 3.240
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