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Literature DB >> 9818165

Forces on adhesive contacts affect cell function.

Abstract

Cellular forces acting on the adhesive contacts made with the extracellular matrix (ECM) contribute significantly to cell shape, viability, signal transduction and motility. In the past two years, research has determined how cell spreading influences cell viability as well as cytoskeletal organization. The cytoskeleton generates a level of tension against the ECM that is proportional to ECM stiffness. The strength of this tension exerted against the ECM affects the migratory speed of the cell.

Mesh：

Year: 1998 PMID： 9818165 DOI： 10.1016/s0955-0674(98)80030-6

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

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Cited

53 in total

1. Migration of keratinocytes through tunnels of digested fibrin.

Authors: V Ronfard; Y Barrandon
Journal: Proc Natl Acad Sci U S A Date: 2001-03-27 Impact factor: 11.205

2. Traction force microscopy of migrating normal and H-ras transformed 3T3 fibroblasts.

Authors: S Munevar; Y Wang ; M Dembo
Journal: Biophys J Date: 2001-04 Impact factor: 4.033

3. Cross-linking of cell surface receptors enhances cooperativity of molecular adhesion.

Authors: A Chen; V T Moy
Journal: Biophys J Date: 2000-06 Impact factor: 4.033

4. Cells lying on a bed of microneedles: an approach to isolate mechanical force.

Authors: John L Tan; Joe Tien; Dana M Pirone; Darren S Gray; Kiran Bhadriraju; Christopher S Chen
Journal: Proc Natl Acad Sci U S A Date: 2003-01-27 Impact factor: 11.205

5. Cell organization in soft media due to active mechanosensing.

Authors: I B Bischofs; U S Schwarz
Journal: Proc Natl Acad Sci U S A Date: 2003-07-25 Impact factor: 11.205

6. Calculation of forces at focal adhesions from elastic substrate data: the effect of localized force and the need for regularization.

Authors: U S Schwarz; N Q Balaban; D Riveline; A Bershadsky; B Geiger; S A Safran
Journal: Biophys J Date: 2002-09 Impact factor: 4.033

Forces on adhesive contacts affect cell function.

1. Migration of keratinocytes through tunnels of digested fibrin.

2. Traction force microscopy of migrating normal and H-ras transformed 3T3 fibroblasts.

3. Cross-linking of cell surface receptors enhances cooperativity of molecular adhesion.

4. Cells lying on a bed of microneedles: an approach to isolate mechanical force.

5. Cell organization in soft media due to active mechanosensing.

6. Calculation of forces at focal adhesions from elastic substrate data: the effect of localized force and the need for regularization.

7. ZF21 protein regulates cell adhesion and motility.

8. Optimization of traction force microscopy for micron-sized focal adhesions.

Review 9. Review of cellular mechanotransduction on micropost substrates.

10. Human brain microvascular endothelial cells resist elongation due to shear stress.