Literature DB >> 9818143

Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products.

J Handelsman1, M R Rondon, S F Brady, J Clardy, R M Goodman.   

Abstract

Cultured soil microorganisms have provided a rich source of natural-product chemistry. Because only a tiny fraction of soil microbes from soil are readily cultured, soil might be the greatest untapped resource for novel chemistry. The concept of cloning the metagenome to access the collective genomes and the biosynthetic machinery of soil microflora is explored here.

Entities:  

Mesh：

Year:  1998        PMID： 9818143     DOI： 10.1016/s1074-5521(98)90108-9

Source DB:  PubMed          Journal:  Chem Biol        ISSN： 1074-5521


  346 in total

Review 1.  Chemical genetics: ligand-based discovery of gene function.

Authors:  B R Stockwell
Journal:  Nat Rev Genet       Date:  2000-11       Impact factor: 53.242

2.  Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms.

Authors:  M R Rondon; P R August; A D Bettermann; S F Brady; T H Grossman; M R Liles; K A Loiacono; B A Lynch; I A MacNeil; C Minor; C L Tiong; M Gilman; M S Osburne; J Clardy; J Handelsman; R M Goodman
Journal:  Appl Environ Microbiol       Date:  2000-06       Impact factor: 4.792

3.  Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin.

Authors:  Amani Zewail; Michael W Xie; Yi Xing; Lan Lin; P Fred Zhang; Wei Zou; Jonathan P Saxe; Jing Huang
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-03       Impact factor: 11.205

4.  A census of rRNA genes and linked genomic sequences within a soil metagenomic library.

Authors:  Mark R Liles; Brian F Manske; Scott B Bintrim; Jo Handelsman; Robert M Goodman
Journal:  Appl Environ Microbiol       Date:  2003-05       Impact factor: 4.792

5.  Mechanisms underlying the impact of humic acids on DNA quantification by SYBR Green I and consequences for the analysis of soils and aquatic sediments.

Authors:  Hubert Zipper; Christiane Buta; Katrin Lämmle; Herwig Brunner; Jürgen Bernhagen; Frank Vitzthum
Journal:  Nucleic Acids Res       Date:  2003-04-01       Impact factor: 16.971

Review 6.  Techniques used to characterize the gut microbiota: a guide for the clinician.

Authors:  Marianne H Fraher; Paul W O'Toole; Eamonn M M Quigley
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2012-03-27       Impact factor: 46.802

7.  Metagenomic analysis of Surti buffalo (Bubalus bubalis) rumen: a preliminary study.

Authors:  Krishna M Singh; Viral B Ahir; Ajai K Tripathi; Umed V Ramani; Manisha Sajnani; Prakash G Koringa; Subhash Jakhesara; Paresh R Pandya; Dharamsi N Rank; Duggirala S Murty; Ramesh K Kothari; Chaitanya G Joshi
Journal:  Mol Biol Rep       Date:  2011-09-27       Impact factor: 2.316

8.  Describing microbial communities and performing global comparisons in the 'omic era.

Authors:  Tom O Delmont; Pascal Simonet; Timothy M Vogel
Journal:  ISME J       Date:  2012-06-21       Impact factor: 10.302

Review 9.  From structure to function: the ecology of host-associated microbial communities.

Authors:  Courtney J Robinson; Brendan J M Bohannan; Vincent B Young
Journal:  Microbiol Mol Biol Rev       Date:  2010-09       Impact factor: 11.056

Review 10.  New extremophilic lipases and esterases from metagenomics.

Authors:  Olalla López-López; Maria E Cerdán; Maria I González Siso
Journal:  Curr Protein Pept Sci       Date:  2014       Impact factor: 3.272
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.