Literature DB >> 9817440

Humoral immunity in the central nervous system of Lewis rats infected with Borna disease virus.

C G Hatalski1, W F Hickey, W I Lipkin.   

Abstract

The aim of this study was to investigate the humoral immune response to Borna disease (BD) virus in the brain of experimentally infected Lewis rats. Abundant IgG was detected in BD-rat brain with isotype variation throughout infection. IgG was locally produced as indicated by an intact blood-brain barrier, Ig kappa light chain mRNA-containing cells in brain and accumulation of virus-specific antibodies in cerebrospinal fluid. Treatment with BD-rat serum altered viral gene expression in persistently infected cultured rat glioblastoma cells. These data suggest that antibodies, produced in the brain, may influence viral gene expression.

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Year:  1998        PMID： 9817440     DOI： 10.1016/s0165-5728(98)00066-6

Source DB:  PubMed          Journal:  J Neuroimmunol        ISSN： 0165-5728            Impact factor:   3.478


  8 in total

1.  Prevention of virus persistence and protection against immunopathology after Borna disease virus infection of the brain by a novel Orf virus recombinant.

Authors:  Marco Henkel; Oliver Planz; Timo Fischer; Lothar Stitz; Hanns-Joachim Rziha
Journal:  J Virol       Date:  2005-01       Impact factor: 5.103

2.  High-dose Borna disease virus infection induces a nucleoprotein-specific cytotoxic T-lymphocyte response and prevention of immunopathology.

Authors:  E Furrer; T Bilzer; L Stitz; O Planz
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

3.  Neutralizing antibodies in persistent borna disease virus infection: prophylactic effect of gp94-specific monoclonal antibodies in preventing encephalitis.

Authors:  E Furrer; T Bilzer; L Stitz; O Planz
Journal:  J Virol       Date:  2001-01       Impact factor: 5.103

4.  Long-term presence of virus-specific plasma cells in sensory ganglia and spinal cord following intravaginal inoculation of herpes simplex virus type 2.

Authors:  Gregg N Milligan; Michael G Meador; Chin-Fun Chu; Christal G Young; Talitha L Martin; Nigel Bourne
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

5.  Effects of human immunodeficiency virus encephalitis and drug abuse on the B lymphocyte population of the brain.

Authors:  Iain C Anthony; Dorothy H Crawford; Jeanne E Bell
Journal:  J Neurovirol       Date:  2004-06       Impact factor: 2.643

6.  Vascular disruption and the role of angiogenic proteins after spinal cord injury.

Authors:  Michelle T L Ng; Anthea T Stammers; Brian K Kwon
Journal:  Transl Stroke Res       Date:  2011-10-13       Impact factor: 6.829

Review 7.  Borna disease virus.

Authors:  I Jordan; W I Lipkin
Journal:  Rev Med Virol       Date:  2001 Jan-Feb       Impact factor: 6.989

Review 8.  Immune responses to RNA-virus infections of the CNS.

Authors:  Diane E Griffin
Journal:  Nat Rev Immunol       Date:  2003-06       Impact factor: 53.106
  8 in total

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