| Literature DB >> 9815242 |
Y Taoufik1, J Gasnault, A Karaterki, M Pierre Ferey, E Marchadier, C Goujard, A Lannuzel, J F Delfraissy, E Dussaix.
Abstract
JC virus (JCV) load was determined by using quantitative polymerase chain reaction in cerebrospinal fluid (CSF) of 12 patients with AIDS-associated progressive multifocal leukoencephalopathy (PML) and compared with clinical outcome. JCV loads varied widely (3-7 log10 JCV equivalents/mL of CSF) and were apparently not related to absolute CD4 cell counts or CSF and plasma human immunodeficiency virus type 1 loads. A significant correlation was observed between JCV load and survival time (Spearman's rank correlation, -0.83; P<. 01). Moreover, CSF JCV load decreased and then became undetectable in 1 PML patient receiving cidofovir treatment, and this was associated with clinical improvement. These results show that CSF JCV load may be useful as a prognostic parameter and in monitoring the effectiveness of anti-JCV therapies in PML patients.Entities:
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Year: 1998 PMID： 9815242 DOI： 10.1086/314496
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226