Literature DB >> 9813377

Surfactant protein A (SP-A) gene targeted mice.

T R Korfhagen1, A M LeVine, J A Whitsett.   

Abstract

Mice lacking surfactant protein A (SP-A) mRNA and protein in vivo were generated using gene targeting techniques. SP-A (-/-) mice have normal levels of SP-B, SP-C and SP-D mRNA and protein and survive and breed normally in vivarium conditions. Phospholipid composition, secretion and clearance, and incorporation of phospholipid precursors are normal in the SP-A (-/-) mice. Lungs of SP-A (-/-) mice have markedly decreased tubular myelin figures and clear Group B streptococci and Pseudomonas aeruginosa less efficiently than SP-A wild type mice. These studies of SP-A (-/-) mice demonstrate that SP-A has an important role in the innate immune system of the lung in vivo.

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Year:  1998        PMID： 9813377     DOI： 10.1016/s0925-4439(98)00075-1

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  22 in total

1.  Surfactant protein-A as an anti-inflammatory component in the amnion: implications for human pregnancy.

Authors:  Deug-Chan Lee; Roberto Romero; Chong Jai Kim; Tinnakorn Chaiworapongsa; Adi L Tarca; JoonHo Lee; Yeon-Lim Suh; Shali Mazaki-Tovi; Edi Vaisbuch; Pooja Mittal; Sorin Draghici; Offer Erez; Juan Pedro Kusanovic; Sonia S Hassan; Jung-Sun Kim
Journal:  J Immunol       Date:  2010-05-03       Impact factor: 5.422

2.  Pulmonary surfactant protein a is expressed in mouse retina by Müller cells and impacts neovascularization in oxygen-induced retinopathy.

Authors:  Faizah Bhatti; Genevieve Ball; Ronald Hobbs; Annette Linens; Saad Munzar; Rizwan Akram; Alistair J Barber; Michael Anderson; Michael Elliott; Madeline Edwards
Journal:  Invest Ophthalmol Vis Sci       Date:  2014-11-18       Impact factor: 4.799

3.  Protective role of lung surfactant protein D in a murine model of invasive pulmonary aspergillosis.

Authors:  T Madan; U Kishore; M Singh; P Strong; E M Hussain; K B Reid; P U Sarma
Journal:  Infect Immun       Date:  2001-04       Impact factor: 3.441

4.  Surfactant protein A2 mutations associated with pulmonary fibrosis lead to protein instability and endoplasmic reticulum stress.

Authors:  Meenakshi Maitra; Yongyu Wang; Robert D Gerard; Carole R Mendelson; Christine Kim Garcia
Journal:  J Biol Chem       Date:  2010-05-13       Impact factor: 5.157

5.  Ultrastructure of Highly Ordered Granules in Alveolar Type II Cells in Several Species.

Authors:  Marian L Miller; Aleksey Porollo; Susan Wert
Journal:  Anat Rec (Hoboken)       Date:  2018-04-06       Impact factor: 2.064

Review 6.  Ureaplasma and BPD.

Authors:  Suhas G Kallapur; Boris W Kramer; Alan H Jobe
Journal:  Semin Perinatol       Date:  2013-04       Impact factor: 3.300

7.  Differences in the BAL proteome after Klebsiella pneumoniae infection in wild type and SP-A-/- mice.

Authors:  Mehboob Ali; Todd M Umstead; Rizwanul Haque; Anatoly N Mikerov; Willard M Freeman; Joanna Floros; David S Phelps
Journal:  Proteome Sci       Date:  2010-06-17       Impact factor: 2.480

8.  Surfactant protein A, an innate immune factor, is expressed in the vaginal mucosa and is present in vaginal lavage fluid.

Authors:  Colin MacNeill; Todd M Umstead; David S Phelps; Zhenwu Lin; Joanna Floros; Debra A Shearer; Judith Weisz
Journal:  Immunology       Date:  2004-01       Impact factor: 7.397

Review 9.  Genetic disorders of surfactant dysfunction.

Authors:  Susan E Wert; Jeffrey A Whitsett; Lawrence M Nogee
Journal:  Pediatr Dev Pathol       Date:  2009 Jul-Aug

10.  Genetic defects in surfactant protein A2 are associated with pulmonary fibrosis and lung cancer.

Authors:  Yongyu Wang; Phillip J Kuan; Chao Xing; Jennifer T Cronkhite; Fernando Torres; Randall L Rosenblatt; J Michael DiMaio; Lisa N Kinch; Nick V Grishin; Christine Kim Garcia
Journal:  Am J Hum Genet       Date:  2008-12-18       Impact factor: 11.025
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