Literature DB >> 9813338

A sequence-specific splicing activator, tra2beta, is up-regulated in response to nerve injury.

S Kiryu-Seo1, N Matsuo, A Wanaka, S Ogawa, M Tohyama, H Kiyama.   

Abstract

Tra2beta is the first mammalian protein which is proved to activate mRNA splicing in sequence-specific manner. Following hypoglossal nerve injury, the expression of Tra2beta mRNA was elevated in injured motoneurons transiently. The up-regulation of Tra2beta mRNA was observed from post-operative day 3 to 21. In addition to the nerve injury in PNS, a brain lesion in CNS also enhanced the expression of Tra2beta mRNA. The present study could be the first observation showing that an expression of the sequence-specific splicing activator is enhanced in neuronal cells in response to nerve injury, and indicates that Tra2beta may participate in the control of injury-specific splicing patterns in order to express molecules which are necessary for regeneration. Copyright 1998 Elsevier Science B.V.

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Year:  1998        PMID： 9813338     DOI： 10.1016/s0169-328x(98)00255-1

Source DB:  PubMed          Journal:  Brain Res Mol Brain Res        ISSN： 0169-328X


  11 in total

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