Literature DB >> 9812780

Rearranged patterns of IgH and TcR gamma genes in patients with acute lymphoblastic leukemia.

S Li1, B Wang, C Li.   

Abstract

The rearrangement of immunoglobulin heavy chain gene (IgH) and T cell receptor gamma gene (TcR gamma) was studied in 30 patients with acute lymphoblastic leukemia (ALL) by the polymerase chain reaction (PCR). 19 cases was found to have rearrangement of IgH gene, 12 of TcR gamma. Most of IgH rearrangement was characterized by one or two specific bands while some had more than two. Rearrangement of TcR gamma gene appeared as one specific band. A slight difference in number, size and lightness of bands was found among the patients. 4 different kinds of rearrangement were observed in the detection of IgH rearrangement in combination with TcR gamma gene. The rearranged patterns of IgH and TcR gamma gene as well as the clinical significance were discussed.

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Year:  1997        PMID： 9812780     DOI： 10.1007/bf02895620

Source DB:  PubMed          Journal:  J Tongji Med Univ        ISSN： 0257-716X


  8 in total

Review 1.  Analysis of immunoglobulin and T cell receptor genes. Part I: Basic and technical aspects.

Authors:  J J van Dongen; I L Wolvers-Tettero
Journal:  Clin Chim Acta       Date:  1991-04       Impact factor: 3.786

2.  VH gene rearrangement events can modify the immunoglobulin heavy chain during progression of B-lineage acute lymphoblastic leukemia.

Authors:  R Wasserman; M Yamada; Y Ito; L R Finger; B A Reichard; S Shane; B Lange; G Rovera
Journal:  Blood       Date:  1992-01-01       Impact factor: 22.113

3.  Detection of clonality in childhood B-lineage acute lymphoblastic leukaemia by the polymerase chain reaction.

Authors:  M N Potter; C G Steward; N J Maitland; A Oakhill
Journal:  Leukemia       Date:  1992-04       Impact factor: 11.528

4.  Multiple rearranged immunoglobulin genes in childhood acute lymphoblastic leukemia of precursor B-cell origin.

Authors:  A Beishuizen; K Hählen; A Hagemeijer; M A Verhoeven; H Hooijkaas; H J Adriaansen; I L Wolvers-Tettero; E R van Wering; J J van Dongen
Journal:  Leukemia       Date:  1991-08       Impact factor: 11.528

5.  Detection of T-cell receptor gamma chain V gene rearrangements using the polymerase chain reaction: application to the study of clonal disease cells in acute lymphoblastic leukemia.

Authors:  J J Taylor; D Rowe; I K Williamson; S E Christmas; S J Proctor; P G Middleton
Journal:  Blood       Date:  1991-05-01       Impact factor: 22.113

6.  Third complementarity determining region (CDR III) sequence analysis in childhood B-lineage acute lymphoblastic leukaemia: implications for the design of oligonucleotide probes for use in monitoring minimal residual disease.

Authors:  C G Steward; M N Potter; A Oakhill
Journal:  Leukemia       Date:  1992-11       Impact factor: 11.528

7.  Prognostic significance of detection of monoclonality in remission marrow in acute lymphoblastic leukemia in childhood. Australian and New Zealand Children's Cancer Study Group.

Authors:  M J Brisco; J Condon; E Hughes; S H Neoh; I Nicholson; P J Sykes; G Tauro; H Ekert; K Waters; I Toogood
Journal:  Leukemia       Date:  1993-10       Impact factor: 11.528

8.  Immunoglobulin heavy chain gene fingerprinting reveals widespread oligoclonality in B-lineage acute lymphoblastic leukaemia.

Authors:  M Deane; H Pappas; J D Norton
Journal:  Leukemia       Date:  1991-10       Impact factor: 11.528
  8 in total

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