Literature DB >> 9811777

Resistance to alpha/beta interferons correlates with the epizootic and virulence potential of Venezuelan equine encephalitis viruses and is determined by the 5' noncoding region and glycoproteins.

D R Spotts1, R M Reich, M A Kalkhan, R M Kinney, J T Roehrig.   

Abstract

We compared the alpha/beta interferon (IFN-alpha/beta) sensitivities of the TC-83 vaccine strain and 24 enzootic and epizootic Venezuelan equine encephalitis (VEE) isolates. The IFN-resistant or -sensitive phenotype correlated well with epizootic or enzootic potential. IFN-alpha/beta resistance of Trinidad donkey (TRD) virus correlated with virulence determinants in the 5' noncoding region and glycoproteins. Infection of mice lacking a functional IFN system with the IFN-sensitive TC-83 virus resulted in disease equivalent to that produced by the virulent, IFN-resistant TRD virus, further demonstrating that IFN resistance contributes to VEE virus virulence and is a biological marker of epizootic potential.

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Year:  1998        PMID： 9811777      PMCID： PMC110615     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  31 in total

1.  Biochemical and antigenic comparison of the envelope glycoproteins of Venezuelan equine encephalomyelitis virus strains.

Authors:  J K France; B C Wyrick; D W Trent
Journal:  J Gen Virol       Date:  1979-09       Impact factor: 3.891

Review 2.  Epizootiology of Venezuelan equine encephalomyelitis in the Americas.

Authors:  T E Walton; K M Johnson
Journal:  J Am Vet Med Assoc       Date:  1972-12-01       Impact factor: 1.936

3.  Antigenic variants of Venezuelan equine encephalitis virus: their geographic distribution and epidemiologic significance.

Authors:  N A Young; K M Johnson
Journal:  Am J Epidemiol       Date:  1969-03       Impact factor: 4.897

4.  Convenient assay for interferons.

Authors:  S Rubinstein; P C Familletti; S Pestka
Journal:  J Virol       Date:  1981-02       Impact factor: 5.103

5.  Arbovirus investigations in Argentina, 1977-1980. III. Identification and characterization of viruses isolated, including new subtypes of western and Venezuelan equine encephalitis viruses and four new bunyaviruses (Las Maloyas, Resistencia, Barranqueras, and Antequera).

Authors:  C H Calisher; T P Monath; C J Mitchell; M S Sabattini; C B Cropp; J Kerschner; A R Hunt; J S Lazuick
Journal:  Am J Trop Med Hyg       Date:  1985-09       Impact factor: 2.345

6.  The role of interferon induction in the interferon sensitivity of the mengovirus mutant, is-1.

Authors:  E H Simon; N Isono; C Bradley
Journal:  J Gen Virol       Date:  1984-01       Impact factor: 3.891

7.  Interferon induction and sensitivity as correlates to virulence of Venezuelan encephalitis viruses for hamsters.

Authors:  P B Jahrling; E Navarro; W F Scherer
Journal:  Arch Virol       Date:  1976       Impact factor: 2.574

8.  Comparative immunological and biochemical analyses of viruses in the Venezuelan equine encephalitis complex.

Authors:  R M Kinney; D W Trent; J K France
Journal:  J Gen Virol       Date:  1983-01       Impact factor: 3.891

9.  Identification of a new Venezuelan equine encephalitis virus from Brazil.

Authors:  C H Calisher; R M Kinney; O de Souza Lopes; D W Trent; T P Monath; D B Francy
Journal:  Am J Trop Med Hyg       Date:  1982-11       Impact factor: 2.345

10.  Infections of congenitally athymic (nude) and normal mice with avirulent and virulent strains of Venezuelan encephalitis virus.

Authors:  P A LeBlanc; W F Scherer; D H Sussdorf
Journal:  Infect Immun       Date:  1978-09       Impact factor: 3.441
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  28 in total

1.  Treatment of Venezuelan equine encephalitis virus infection with (-)-carbodine.

Authors:  Justin G Julander; Richard A Bowen; Jagadeeshwar R Rao; Craig Day; Kristiina Shafer; Donald F Smee; John D Morrey; Chung K Chu
Journal:  Antiviral Res       Date:  2008-08-15       Impact factor: 5.970

2.  A determinant of Sindbis virus neurovirulence enables efficient disruption of Jak/STAT signaling.

Authors:  Jason D Simmons; Amy C Wollish; Mark T Heise
Journal:  J Virol       Date:  2010-08-25       Impact factor: 5.103

3.  Positively charged amino acid substitutions in the e2 envelope glycoprotein are associated with the emergence of venezuelan equine encephalitis virus.

Authors:  Aaron C Brault; Ann M Powers; Edward C Holmes; C H Woelk; Scott C Weaver
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

4.  Pegylated alpha interferon is an effective treatment for virulent venezuelan equine encephalitis virus and has profound effects on the host immune response to infection.

Authors:  R A Lukaszewski; T J Brooks
Journal:  J Virol       Date:  2000-06       Impact factor: 5.103

5.  An alphavirus replicon particle chimera derived from venezuelan equine encephalitis and sindbis viruses is a potent gene-based vaccine delivery vector.

Authors:  Silvia Perri; Catherine E Greer; Kent Thudium; Barbara Doe; Harold Legg; Hong Liu; Raul E Romero; Zequn Tang; Qian Bin; Thomas W Dubensky; Michael Vajdy; Gillis R Otten; John M Polo
Journal:  J Virol       Date:  2003-10       Impact factor: 5.103

6.  Variation in interferon sensitivity and induction among strains of eastern equine encephalitis virus.

Authors:  Patricia V Aguilar; Slobodan Paessler; Anne-Sophie Carrara; Samuel Baron; Joyce Poast; Eryu Wang; Abelardo C Moncayo; Michael Anishchenko; Douglas Watts; Robert B Tesh; Scott C Weaver
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

7.  Imported lassa fever in Germany: molecular characterization of a new lassa virus strain.

Authors:  S Günther; P Emmerich; T Laue; O Kühle; M Asper; A Jung; T Grewing; J ter Meulen; H Schmitz
Journal:  Emerg Infect Dis       Date:  2000 Sep-Oct       Impact factor: 6.883

8.  Structural and nonstructural protein genome regions of eastern equine encephalitis virus are determinants of interferon sensitivity and murine virulence.

Authors:  Patricia V Aguilar; A Paige Adams; Eryu Wang; Wenli Kang; Anne-Sophie Carrara; Michael Anishchenko; Ilya Frolov; Scott C Weaver
Journal:  J Virol       Date:  2008-03-19       Impact factor: 5.103

9.  Selection of functional 5' cis-acting elements promoting efficient sindbis virus genome replication.

Authors:  Rodion Gorchakov; Richard Hardy; Charles M Rice; Ilya Frolov
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103

10.  Generation and characterization of closely related epizootic and enzootic infectious cDNA clones for studying interferon sensitivity and emergence mechanisms of Venezuelan equine encephalitis virus.

Authors:  Michael Anishchenko; Slobodan Paessler; Ivorlyne P Greene; Patricia V Aguilar; Anne-Sophie Carrara; Scott C Weaver
Journal:  J Virol       Date:  2004-01       Impact factor: 5.103
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