Literature DB >> 9811673

The Escherichia coli cmlA gene encodes the multidrug efflux pump Cmr/MdfA and is responsible for isopropyl-beta-D-thiogalactopyranoside exclusion and spectinomycin sensitivity.

C Bohn1, P Bouloc.   

Abstract

Expression of cloned genes from isopropyl-beta-D-thiogalactopyranoside (IPTG)-regulated promoters is lowered when the Escherichia coli CmlA/Cmr/MdfA efflux pump is overexpressed, probably due to IPTG exclusion from the cytoplasm. The previously reported cmlA1 mutation confers a similar phenotype. cmlA1 contains an IS30 insertion upstream of cmr/mdfA, which creates a putative promoter. CmlA overproduction also causes spectinomycin hypersensitivity.

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Year:  1998        PMID： 9811673      PMCID： PMC107689     

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  28 in total

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Authors:  Y Y Chang; J E Cronan
Journal:  J Bacteriol       Date:  1983-05       Impact factor: 3.490
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  22 in total

1.  Escherichia coli gene ydeA encodes a major facilitator pump which exports L-arabinose and isopropyl-beta-D-thiogalactopyranoside.

Authors:  S Carolé; S Pichoff; J P Bouch
Journal:  J Bacteriol       Date:  1999-08       Impact factor: 3.490

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Authors:  M Putman; H W van Veen; W N Konings
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3.  TorI, a response regulator inhibitor of phage origin in Escherichia coli.

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Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-14       Impact factor: 11.205

4.  Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants Selected with a fluoroquinolone.

Authors:  A S Jellen-Ritter; W V Kern
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

5.  Species-specific activity of antibacterial drug combinations.

Authors:  Ana Rita Brochado; Anja Telzerow; Jacob Bobonis; Manuel Banzhaf; André Mateus; Joel Selkrig; Emily Huth; Stefan Bassler; Jordi Zamarreño Beas; Matylda Zietek; Natalie Ng; Sunniva Foerster; Benjamin Ezraty; Béatrice Py; Frédéric Barras; Mikhail M Savitski; Peer Bork; Stephan Göttig; Athanasios Typas
Journal:  Nature       Date:  2018-07-04       Impact factor: 49.962

6.  Characterization of SotA and SotB, two Erwinia chrysanthemi proteins which modify isopropyl-beta-D-thiogalactopyranoside and lactose induction of the Escherichia coli lac promoter.

Authors:  G Condemine
Journal:  J Bacteriol       Date:  2000-03       Impact factor: 3.490

7.  Structural comparison of bacterial multidrug efflux pumps of the major facilitator superfamily.

Authors:  Indrika Ranaweera; Ugina Shrestha; K C Ranjana; Prathusha Kakarla; T Mark Willmon; Alberto J Hernandez; Mun Mun Mukherjee; Sharla R Barr; Manuel F Varela
Journal:  Trends Cell Mol Biol       Date:  2015

8.  Alkalitolerance: a biological function for a multidrug transporter in pH homeostasis.

Authors:  Oded Lewinson; Etana Padan; Eitan Bibi
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-15       Impact factor: 11.205

Review 9.  Efflux-mediated drug resistance in bacteria.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2004       Impact factor: 9.546

10.  Global analysis of extracytoplasmic stress signaling in Escherichia coli.

Authors:  Stéphanie Bury-Moné; Yanoura Nomane; Nancie Reymond; Romain Barbet; Eric Jacquet; Sandrine Imbeaud; Annick Jacq; Philippe Bouloc
Journal:  PLoS Genet       Date:  2009-09-18       Impact factor: 5.917
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