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Literature DB >> 9811624

Linking extracellular survival signals and the apoptotic machinery.

Abstract

The survival of cells in multicellular organisms requires continuous stimulation from the extracellular environment. The phosphatidylinositol-3' kinase/Akt signaling cascade has been identified as a critical pathway for the transduction of extracellular survival signals. The finding that the pro-apoptotic protein BAD is a substrate of Akt/PKB has provided the first link between extracellular survival signals and the apoptotic machinery.

Entities: Gene

Mesh：

Year: 1998 PMID： 9811624 DOI： 10.1016/s0959-4388(98)80089-5

Source DB: PubMed Journal: Curr Opin Neurobiol ISSN： 0959-4388 Impact factor: 6.627

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Cited

16 in total

1. Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells.

Authors: A Danilkovitch; S Donley; A Skeel; E J Leonard
Journal: Mol Cell Biol Date: 2000-03 Impact factor: 4.272

2. Low-dose erythropoietin inhibits oxidative stress and early vascular changes in the experimental diabetic retina.

Authors: Q Wang; F Pfister; A Dorn-Beineke; F vom Hagen; J Lin; Y Feng; H P Hammes
Journal: Diabetologia Date: 2010-03-26 Impact factor: 10.122

3. A neuroprotective herbal mixture inhibits caspase-3-independent apoptosis in retinal ganglion cells.

Authors: Zelda H Cheung; Mason C P Leung; Henry K Yip; Wutian Wu; Flora K W Siu; Kwok-Fai So
Journal: Cell Mol Neurobiol Date: 2007-08-21 Impact factor: 5.046

Review 4. Neuroprotection and acute spinal cord injury: a reappraisal.

Authors: Edward D Hall; Joe E Springer
Journal: NeuroRx Date: 2004-01

5. Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3'-kinase/protein kinase B signaling.

Authors: N Klöcker; P Kermer; J H Weishaupt; M Labes; R Ankerhold; M Bähr
Journal: J Neurosci Date: 2000-09-15 Impact factor: 6.167

6. The calcium-independent protein kinase C participates in an early process of CD3/CD28-mediated induction of thymocyte apoptosis.

Authors: A Asada; Y Zhao; H Komano; T Kuwata; M Mukai; K Fujita; Y Tozawa; R Iseki; H Tian; K Sato; Y Motegi; R Suzuki; M Yokoyama; M Iwata
Journal: Immunology Date: 2000-11 Impact factor: 7.397

Linking extracellular survival signals and the apoptotic machinery.

1. Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells.

2. Low-dose erythropoietin inhibits oxidative stress and early vascular changes in the experimental diabetic retina.

3. A neuroprotective herbal mixture inhibits caspase-3-independent apoptosis in retinal ganglion cells.

Review 4. Neuroprotection and acute spinal cord injury: a reappraisal.

5. Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3'-kinase/protein kinase B signaling.

6. The calcium-independent protein kinase C participates in an early process of CD3/CD28-mediated induction of thymocyte apoptosis.

7. Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts.

8. Three-dimensional cell grafting enhances the angiogenic efficacy of human umbilical vein endothelial cells.

Review 9. Transforming growth factor-beta and ischemic brain injury.

10. Rac1 inhibits apoptosis in human lymphoma cells by stimulating Bad phosphorylation on Ser-75.