Literature DB >> 9810272

Betulinic acid inhibits aminopeptidase N activity.

M F Melzig, H Bormann.   

Abstract

The triterpene betulinic acid inhibits the activity of aminopeptidase N (EC 3.4.11.2) in a dose-dependent manner. An IC50 of 7.3 +/- 1.4 microM was determined for betulinic acid. This inhibitory activity is higher than that of bestatin' (IC50 = 16.9 +/- 4.1 microM), a well known inhibitor of this enzyme. The finding supports the idea that betulinic acid acts as anti-melanoma agent via inhibition of aminopeptidase N activity.

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Year:  1998        PMID： 9810272     DOI： 10.1055/s-2006-957542

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  8 in total

1.  Lupane triterpenoids--betulin and betulinic acid derivatives induce apoptosis in tumor cells.

Authors:  Harish Kommera; Goran N Kaluđerović; Jutta Kalbitz; Reinhard Paschke
Journal:  Invest New Drugs       Date:  2009-12-04       Impact factor: 3.850

2.  Betulinic acid enhances TGF-β signaling by altering TGF-β receptors partitioning between lipid-raft/caveolae and non-caveolae membrane microdomains in mink lung epithelial cells.

Authors:  C L Chen; C Y Chen; Y P Chen; Y B Huang; M W Lin; D C Wu; H T Huang; M Y Liu; H W Chang; Y C Kao; P H Yang
Journal:  J Biomed Sci       Date:  2016-02-27       Impact factor: 8.410

3.  Betulinic acid inhibits growth factor-induced in vitro angiogenesis via the modulation of mitochondrial function in endothelial cells.

Authors:  Ho Jeong Kwon; Joong Sup Shim; Jin Hee Kim; Hyun Young Cho; Young Na Yum; Seung Hee Kim; Jaehoon Yu
Journal:  Jpn J Cancer Res       Date:  2002-04

Review 4.  Metallo-aminopeptidase inhibitors.

Authors:  Artur Mucha; Marcin Drag; John P Dalton; Paweł Kafarski
Journal:  Biochimie       Date:  2010-05-10       Impact factor: 4.079

Review 5.  Aminopeptidase-N/CD13 (EC 3.4.11.2) inhibitors: chemistry, biological evaluations, and therapeutic prospects.

Authors:  Brigitte Bauvois; Daniel Dauzonne
Journal:  Med Res Rev       Date:  2006-01       Impact factor: 12.944

6.  Betulinic Acid for cancer treatment and prevention.

Authors:  Simone Fulda
Journal:  Int J Mol Sci       Date:  2008-06-27       Impact factor: 6.208

7.  The effect of 3β, 6β, 16β-trihydroxylup-20(29)-ene lupane compound isolated from Combretum leprosum Mart. on peripheral blood mononuclear cells.

Authors:  Fabianne Lacouth-Silva; Caroline V Xavier; Sulamita da S Setúbal; Adriana S Pontes; Neriane M Nery; Onassis Boeri de Castro; Carla F C Fernandes; Eduardo R Honda; Fernando B Zanchi; Leonardo A Calderon; Rodrigo G Stábeli; Andreimar M Soares; Izaltina Silva-Jardim; Valdir A Facundo; Juliana P Zuliani
Journal:  BMC Complement Altern Med       Date:  2015-11-25       Impact factor: 3.659

8.  Betulinic Acid Exerts Cytotoxic Activity Against Multidrug-Resistant Tumor Cells via Targeting Autocrine Motility Factor Receptor (AMFR).

Authors:  Mohamed E M Saeed; Nuha Mahmoud; Yoshikazu Sugimoto; Thomas Efferth; Heba Abdel-Aziz
Journal:  Front Pharmacol       Date:  2018-05-15       Impact factor: 5.810
  8 in total

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